Cushing’s Disease in a 7-Month-Old Girl due to a Tumor Producing Adrenocorticotropic Hormone and Thyreotropin-Secreting Hormone

Autor: G. Schackert, C. Bonk, T. Pinzer, S. B. Sobottka, J. Koy, J.V. List, A. Huebner
Jazyk: angličtina
Rok vydání: 1999
Předmět:
Adenoma
Pathology
medicine.medical_specialty
Pituitary gland
endocrine system
endocrine system diseases
Thyrotropin
Adrenocorticotropic hormone
Pituitary neoplasm
Hypophysenadenom
Adrenocorticotropin
ACTH
Thyreoidea-stimulierendes Hormon
TSH
Cushing-Syndrom
Neurochirurgie
Cushing syndrome
Adrenocorticotropic Hormone
Thyroid-stimulating hormone
GTP-Binding Proteins
Pituitary adenoma
Internal medicine
medicine
Humans
Pituitary Neoplasms
ddc:610
Cushing Syndrome
business.industry
Pituitary adenoma
Adrenocorticotropic hormone
Thyreotropin-secreting hormone
Cushing’s disease
Cushing’s syndrome
Neurosurgery
Infant
General Medicine
Cushing's disease
medicine.disease
Magnetic Resonance Imaging
Endocrinology
medicine.anatomical_structure
Pediatrics
Perinatology and Child Health
Female
Surgery
Neurology (clinical)
business
hormones
hormone substitutes
and hormone antagonists
Zdroj: Pediatr Neurosurg 1999;31:7–11, ISSN: 1016-2291
Popis: We present the case of a 7-month-old baby with Cushing’s disease due to an adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma combined with cells producing thyreotropin-secreting hormone (TSH). In MRI scans, a contrast-enhancing lesion was seen inside the pituitary fossa, and it extended into the suprasellar region. On the assumption of a pituitary adenoma, surgery was performed. Corresponding with biochemical findings, histopathological evaluation revealed an ACTH- and TSH-producing tumor. Genetic analysis did not demonstrate an alteration at codon 201 (Arg) and 227 (Glu). To our knowledge, this is the first case described in a child of this age. Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich.
Databáze: OpenAIRE
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