The Influence of the Exclusion of Central Necrosis on [(18)F]FDG PET Radiomic Analysis
| Autor: | Floris H. P. van Velden, Henri J L M Timmers, Anouk van Berkel, Wyanne A. Noortman, Charlotte D.Y. Mooij, Dennis Vriens, Erik H.J.G. Aarntzen, Tineke W.H. Meijer, Cornelis H. Slump, Johan Bussink, Lioe-Fee de Geus-Oei |
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| Přispěvatelé: | Biomedical Photonic Imaging, TechMed Centre, Robotics and Mechatronics |
| Rok vydání: | 2021 |
| Předmět: |
Medicine (General)
medicine.medical_specialty Volume of interest CELL LUNG-CANCER FEATURES Clinical Biochemistry lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] radiomics [18F]FDG PET/CT tumour delineation central necrosis Central necrosis 030218 nuclear medicine & medical imaging 18f fdg pet 03 medical and health sciences R5-920 0302 clinical medicine Radiomics Medicine F-18-FDG PET HETEROGENEITY Receiver operating characteristic business.industry Vascular damage Radboud Institute for Molecular Life Sciences [Radboudumc 16] Tumour delineation TUMOR DELINEATION Women's cancers Radboud Institute for Health Sciences [Radboudumc 17] [F]FDG PET/CT 3. Good health [F-18]FDG PET/CT 030220 oncology & carcinogenesis VOLUME Tracer uptake Fdg pet ct Radiology business REPEATABILITY Rare cancers Radboud Institute for Health Sciences [Radboudumc 9] |
| Zdroj: | Diagnostics, 11 Diagnostics, 11, 7 Diagnostics, 11(7):1296. MDPI AG Diagnostics, Vol 11, Iss 1296, p 1296 (2021) Diagnostics, 11(7):1296. MDPI Diagnostics, 11(7) Diagnostics; Volume 11; Issue 7; Pages: 1296 |
| ISSN: | 2075-4418 |
| Popis: | Contains fulltext : 238088.pdf (Publisher’s version ) (Open Access) BACKGROUND: Central necrosis can be detected on [(18)F]FDG PET/CT as a region with little to no tracer uptake. Currently, there is no consensus regarding the inclusion of regions of central necrosis during volume of interest (VOI) delineation for radiomic analysis. The aim of this study was to assess how central necrosis affects radiomic analysis in PET. METHODS: Forty-three patients, either with non-small cell lung carcinomas (NSCLC, n = 12) or with pheochromocytomas or paragangliomas (PPGL, n = 31), were included retrospectively. VOIs were delineated with and without central necrosis. From all VOIs, 105 radiomic features were extracted. Differences in radiomic features between delineation methods were assessed using a paired t-test with Benjamini-Hochberg multiple testing correction. In the PPGL cohort, performances of the radiomic models to predict the noradrenergic biochemical profile were assessed by comparing the areas under the receiver operating characteristic curve (AUC) for both delineation methods. RESULTS: At least 65% of the features showed significant differences between VOI(vital-tumour) and VOI(gross-tumour) (65%, 79% and 82% for the NSCLC, PPGL and combined cohort, respectively). The AUCs of the radiomic models were not significantly different between delineation methods. CONCLUSION: In both tumour types, almost two-third of the features were affected, demonstrating that the impact of whether or not to include central necrosis in the VOI on the radiomic feature values is significant. Nevertheless, predictive performances of both delineation methods were comparable. We recommend that radiomic studies should report whether or not central necrosis was included during delineation. |
| Databáze: | OpenAIRE |
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