Defective Regulation of Immune Responses in Croup Due to Parainfluenza Virus
| Autor: | Martha Sun, Deborah Rinaldo, Robert C. Welliver |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Lymphocyte Activation
Immunoglobulin E Pathogenesis chemistry.chemical_compound Laryngitis Immune system Antigen Immunopathology otorhinolaryngologic diseases medicine Humans Child Antigens Viral Respiratory Tract Infections Croup Paramyxoviridae Infections biology Infant medicine.disease Virology chemistry Bronchiolitis Child Preschool Antibody Formation Pediatrics Perinatology and Child Health Immunology biology.protein Histamine |
| Zdroj: | Pediatric Research. 19:716-720 |
| ISSN: | 1530-0447 0031-3998 |
| DOI: | 10.1203/00006450-198507000-00016 |
| Popis: | In order to determine if defects in regulation of immune responses play a role in the pathogenesis of croup, we studied 37 infants and children with either croup or upper respiratory illness alone due to parainfluenza virus (PV). PV-specific IgE responses were determined by an enzyme-linked immunosorbent assay, cell-mediated immune responses to PV antigen were studied by in vitro lymphocyte transformation assays, and suppressor cell function was determined by addition of histamine to lymphocyte transformation assays. In comparison to patients with upper respiratory illness alone, patients with croup had increased production of PV-specific IgE antibody, increased lymphoproliferative responses to PV antigen, and diminished histamine-induced suppression of lymphocyte transformation responses to PV. These results suggest that a defect in suppressor function exists among croup patients. Similar defects have been demonstrated in bronchiolitis and atopic diseases, providing an immunologic link between the three illnesses. |
| Databáze: | OpenAIRE |
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