Physical exercise for prevention of dementia (EPD) study: background, design and methods
| Autor: | Iuliano E., Di Cagno A., Cristofano A., Angiolillo A., D'Aversa R., Ciccotelli S., Corbi G., Fiorilli G., Calcagno G., Di Costanzo A., Aquino G., Arcari V., Buongusto L., Cavallo G., Faraone M., Ferrara N., Filangieri M., Fiscarelli M., Iavarone S., Iannetta F., Moffa S., Mignogna P., Oriani G., Palombo F., PANICHELLA, NAZARENO, Pedata S., Petti B., Spaziano M., Taglialatela M., Valente R. |
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| Přispěvatelé: | Iuliano, E., Di Cagno, A., Cristofano, A., Angiolillo, A., D'Aversa, R., Ciccotelli, S., Corbi, G., Fiorilli, G., Calcagno, G., Di Costanzo, A., Aquino, G., Arcari, V., Buongusto, L., Cavallo, G., Faraone, M., Ferrara, N., Filangieri, M., Fiscarelli, M., Iavarone, S., Iannetta, F., Moffa, S., Mignogna, P., Oriani, G., Palombo, F., Panichella, Nazareno, Pedata, S., Petti, B., Spaziano, M., Taglialatela, M., Valente, R. |
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Aging population 030209 endocrinology & metabolism Physical exercise Prevention of dementia Risk Assessment law.invention Study Protocol 03 medical and health sciences Cognition 0302 clinical medicine Double-Blind Method Randomized controlled trial Memory law Humans Medicine Dementia Cognitive Dysfunction 030212 general & internal medicine Cognitive decline Exercise Aged Mild cognitive impairment Neuropsychological test Physical activity Subjective memory complaints Subjective memory complaint business.industry lcsh:Public aspects of medicine Public Health Environmental and Occupational Health lcsh:RA1-1270 Middle Aged medicine.disease Cognitive test Physical therapy Female Observational study Independent Living business Program Evaluation |
| Zdroj: | BMC Public Health, Vol 19, Iss 1, Pp 1-9 (2019) BMC Public Health |
| ISSN: | 1471-2458 |
| DOI: | 10.1186/s12889-019-7027-3 |
| Popis: | Background Several observational studies have shown that exercise reduces the risk of cognitive decline; however, evidences from long-term, well-conducted, randomized controlled trials are scanty. The principal aim of this study is to verify whether a long-term program of multimodal supervised exercise improves the cognitive function and/or reduces the rate of cognitive decline in older adults at different degrees of risk for dementia. Methods/design EPD is a parallel group, double-blind, randomized controlled trial. Community-dwelling volunteers aged 50 years or more are being recruited from different community centers and screened for eligibility. Enrolled subjects are being divided in 3 groups: a) without subjective or objective cognitive impairment, b) with subjective memory complaints, and c) with mild cognitive impairments. Participants in each group (at least 180) are being randomly assigned (1:1) to an experimental group, performing a supervised training including aerobic and resistance exercises of moderate/high intensity, or to a control group. Primary outcome will be 48-months changes in Mini Mental State Examinations. Secondary outcomes will be changes in several cognitive tests including a composite cognitive score. Time points will be at baseline, and at 6, 12, 24, 36 and 48 months. Statistical analysis will be done as intention to treat, complete case and mixed model analysis. Discussion EPD is the first trial to examine the effects of a long exercise program (48 months) on cognitive performances. If successful, this trial may provide evidence for using long-term and multimodal exercise interventions for dementia prevention programs in the aging population. Trial registration The study is registered at ClinicalTrials.gov with the code NCT02236416. |
| Databáze: | OpenAIRE |
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