Retinal vascular abnormalities in schizophrenia and bipolar disorder

Autor: Ananth Padmanabha, Chaitra V. Hiremath, Ganesan Venkatasubramanian, Carroll A.B. Webers, Naren P. Rao, Bhargavi Nagendra, Shivarama Varambally, Tos T. J. M. Berendschot, Arpitha Jacob, Dona Maria Chako, Abhishek Appaji, Muralidharan Kesavan, Shyam Vasudeva Rao
Přispěvatelé: Medical Image Analysis, Promovendi MHN, Oogheelkunde, RS: MHeNs - R3 - Neuroscience, MUMC+: *MA Oogheelkunde (3), MUMC+: MA UECM Oogartsen MUMC (9), RS: NUTRIM - R1 - Obesity, diabetes and cardiovascular health
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Bipolar Disorder
Fundus (eye)
SDG 3 – Goede gezondheid en welzijn
chemistry.chemical_compound
0302 clinical medicine
Venules
AREAS
Photography
RATING-SCALE
Stroke
psychoses
RISK
medicine.diagnostic_test
neurodevelopment
PSYCHOTIC SYMPTOMS
Brain
Organ Size
Psychiatry and Mental health
Arterioles
medicine.anatomical_structure
Schizophrenia
RELIABILITY
Female
Schizophrenic Psychology
retinal vessel
STROKE
Optic disc
Adult
medicine.medical_specialty
Fundus Oculi
CALIBER
cerebrovascular event
Age and sex
MECHANISMS
03 medical and health sciences
Young Adult
peripheral marker
SDG 3 - Good Health and Well-being
Ophthalmology
medicine
Humans
Bipolar disorder
VALIDITY
Biological Psychiatry
business.industry
fundus
Fundus photography
Retinal Vessels
Retinal
medicine.disease
030227 psychiatry
chemistry
Case-Control Studies
business
CHALLENGE
030217 neurology & neurosurgery
Zdroj: Bipolar Disorders, 21(7), 634-641. Wiley
ISSN: 1398-5647
DOI: 10.1111/bdi.12779
Popis: OBJECTIVES: The examination of retinal microvascular abnormalities through fundus photography is currently the best available non-invasive technique for assessment of cerebral vascular status. Several studies in the last decade have reported higher incidences of adverse cerebrovascular events in Schizophrenia (SCZ) and bipolar disorder (BD). However, retinal microvasculature abnormalities in SCZ and BD have remained under-explored, and no study has compared this aspect of SCZ and BD till date.METHODS: Retinal Images of 100 SCZ patients, BD patients, and healthy volunteers each were acquired by trained individuals using a non-mydriatic camera with a 40-degree field of view. The retinal images were quantified using a valid semi-automated method. The average of left and right eye diameters of the venules and arterioles passing through the extended zone between 0.5 and 2 disc diameters from the optic disc were calculated.RESULTS: The groups differed significantly with respect to average diameters of both retinal venules (P < 0.001) and retinal arterioles (P < 0.001), after controlling for age and sex. Both SCZ and BD patients had significantly narrower arterioles and wider venules compared to HV. There were also significant differences between SCZ and BD patients; patients with BD had narrower arterioles and wider venules.CONCLUSION: Considering the affordability and easy accessibility of the investigative procedure, retinal microvascular examination could serve as a potential screening tool to identify individuals at risk for adverse cerebrovascular events. The findings of the current study also provide a strong rationale for further systematic examination of retinal vascular abnormalities in SCZ and BD.
Databáze: OpenAIRE
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