Molecular Recognition Profiles and Clinical Patterns of PR-10 Sensitization in a Birch-Free Mediterranean Area
| Autor: | M. Giani, E. C. Guerra, Maria Locanto, L. Pirrotta, Lorenzo Cecchi, Enrico Scala, Riccardo Asero, Damiano Abeni |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male Allergy Adolescent Immunology Fagales Immunoglobulin E 03 medical and health sciences Young Adult 0302 clinical medicine Oral allergy syndrome Food allergy medicine Hypersensitivity Immunology and Allergy Humans Child Sensitization Betula Aged Plant Proteins Aged 80 and over biology business.industry Order Fagales Infant General Medicine Allergens Antigens Plant Middle Aged medicine.disease biology.organism_classification 030104 developmental biology medicine.anatomical_structure 030228 respiratory system Italy Child Preschool biology.protein Mediterranean area Female business |
| Zdroj: | International archives of allergy and immunology. 173(3) |
| ISSN: | 1423-0097 |
| Popis: | Background: The order Fagales represents an important cause of tree-pollen allergy in northern countries. We investigated the IgE recognition profiles, mutual relationships, and association with clinical symptoms of a panel of allergens belonging to the PR-10 family, the main proteins responsible for Fagales allergy (Act d 8, Aln g 1, Api g 1, Ara h 8, Bet v 1, Cor a 1.0101, Cor a 1.0401, Gly m 4, Mal d 1, and Pru p 1). Methods: A total of 526 PR-10-reactive subjects living in central and southern Italy were studied by ImmunoCAP-ISAC-112 microarray analysis. Results: Overall, Bet v 1 reactivity was the most commonly (74%) observed among PR-10 proteins, but Cor a 1.0101 was the most prevalent in participants aged Conclusions: Testing IgE reactivity to a panel of PR-10s in a birch-free area discloses peculiar relationships between clinical phenotypes and sensitization profiles, allowing the identification of novel cluster patterns. |
| Databáze: | OpenAIRE |
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