Role of Maternal Serum Human Placental Lactogen in First Trimester Screening

Autor: Vijetha Shenoy Belle, Krishnananda Prabhu, Indranil Ghoshal, Varashree Bolar Suryakanth
Rok vydání: 2018
Předmět:
Zdroj: Indian J Clin Biochem
ISSN: 0974-0422
0970-1915
DOI: 10.1007/s12291-018-0750-1
Popis: The most preferred antenatal screening test is first trimester dual test which has a detection rate of 95% for foetal chromosomal anomaly. Maternal serum free β human chorionic gonadotropin (free β hCG) and pregnancy associated plasma protein A are used in first trimester dual test along with maternal demographic and foetal sonographic indices to calculate risk for foetal aneuploidy. Human placental lactogen is a placental hormone that is present in maternal serum only during pregnancy and its level rises in relation to the growth of the foetus and placenta. The objectives of this study was to measure and correlate maternal serum hPL with free β hCG, maternal age, maternal age related risk ratio and calculated risk ratio of first trimester screening. After obtaining permission from the Institutional Ethics Committee, hPL and free β hCG were measured from the serum of 84 pregnant women aged 20–40 years in 11–13th weeks + 6 days of gestation who underwent dual test during their antenatal check-up. Independent t test, Pearson’s correlation, Spearman’s correlation, Mann–Whitney U test, ANOVA were used wherever appropriate. A significant positive correlation between maternal serum hPL, maternal age related aneuploidy risk ratio (p value
Databáze: OpenAIRE
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