Sampling conditions influence multiple electrode platelet aggregometry in cardiac surgery patients
| Autor: | Christine Roman-Emanuel, Caroline Shams Hakimi, Linda Thimour-Bergström, Martin Karlsson, Anders Jeppsson |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Platelet Aggregation Platelet Function Tests medicine.medical_treatment Hirudin Postoperative Hemorrhage Sensitivity and Specificity Citric Acid Hemostatics Thrombin Fibrinolytic Agents Predictive Value of Tests Internal medicine medicine.artery Preoperative Care medicine Humans Platelet Prospective Studies Protamines Coronary Artery Bypass Radial artery Vein Electrodes Aged Postoperative Care Blood Specimen Collection Heparin business.industry Anticoagulants Heparin Antagonists Hirudins Middle Aged Cardiac surgery Adenosine Diphosphate medicine.anatomical_structure Anesthesia Cardiology Female Cardiology and Cardiovascular Medicine business Central venous catheter medicine.drug Blood sampling |
| Zdroj: | Scandinavian Cardiovascular Journal. 47:98-103 |
| ISSN: | 1651-2006 1401-7431 |
| DOI: | 10.3109/14017431.2012.743672 |
| Popis: | To investigate the importance of blood sampling conditions for multiple electrode platelet aggregometry (MEA) in cardiac surgery patients.Eighty-one patients undergoing first time CABG surgery were included in three prospective, observational studies. MEA was used to analyze platelet aggregability after addition of adenosine-diphosphate (ADP) or thrombin activating peptide 6 (TRAP). In substudy 1, hirudin and citrate tubes were compared. In substudy 2, samples from peripheral vein, central venous catheter, and radial artery were compared and in substudy 3, the effect of surgery was investigated by analyzing pre- and postoperative samples.Platelet aggregability values were 30% higher in hirudin tubes than in citrate tubes. There was a significant correlation between hirudin and citrate tubes in TRAP-induced aggregability (r = 0.84, p0.001) but not in ADP-induced aggregability (r = 0.25, p = 0.13). The blood sampling site did not influence platelet aggregability. Surgery reduced ADP-induced aggregability by 31% (p0.001) and TRAP-induced aggregability by 30% (p0.001) with large intraindividual variations.MEA results in cardiac surgery patients should not be compared between samples collected in test tubes with different anticoagulants. The choice of blood sampling site does not affect the results. The operation in itself reduces markedly mean platelet aggregability. |
| Databáze: | OpenAIRE |
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