Highly Efficient Glioma Targeting of Tat Peptide-TTA1 Aptamer-Polyephylene Glycol-Modified Gelatin-Siloxane Nanoparticles
| Autor: | Xiaoning Lin, Xinli Tian, Xinhua Tian, Wei Feng, Wang Li, Jin Sun, Feng Wei, Zhi-Chun Huang |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Materials science food.ingredient Siloxanes Aptamer Biomedical Engineering Bioengineering 02 engineering and technology Polyethylene glycol Conjugated system Blood–brain barrier Gelatin Polyethylene Glycols 03 medical and health sciences chemistry.chemical_compound food Glioma Cell Line Tumor PEG ratio medicine Humans General Materials Science Brain Neoplasms technology industry and agriculture General Chemistry Aptamers Nucleotide 021001 nanoscience & nanotechnology Condensed Matter Physics medicine.disease 030104 developmental biology medicine.anatomical_structure chemistry Blood-Brain Barrier Biophysics Nanoparticles 0210 nano-technology Peptides Preclinical imaging |
| Zdroj: | Journal of nanoscience and nanotechnology. 18(4) |
| ISSN: | 1533-4880 |
| Popis: | Gliomas are the most common type of intracranial malignant tumor; however, current treatment approaches are often ineffective due to limited penetration of genes or drugs through the blood-brain barrier (BBB). Here we describe the synthesis of gelatin-siloxane nanoparticles (GS NPs) as candidate gene carriers through a two-step sol-gel process. To increase the efficiency of glioma targeting, human immunodeficiency virus-derived Tat, tumor-targeting aptamer (TTA)1, and polyethylene glycol (PEG) were conjugated to the GS NPs to generate Tat-TTA1-PEG-GS NPs. In vivo imaging revealed that these modified NPs not only evaded capture by the reticulo-endothelial system, but were able to cross the BBB to reach gliomas. Our results suggest that Tat-TTA1-PEG-GS NPs are a new type of non-viral vector that can deliver therapeutic DNA or drugs for highly efficient glioma treatment. |
| Databáze: | OpenAIRE |
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