Repeated administration of acrylamide for 28 days reduces late-stage progenitor cells and immature granule cells accompanying impaired neurite outgrowth in the adult hippocampal neurogenesis in young-adult rats

Autor:	Bunichiro, Ogawa, Yutaka, Nakanishi, Masaki, Wakamatsu, Yasunori, Takahashi, Makoto, Shibutani
Rok vydání:	2022
Předmět:	Male Doublecortin Domain Proteins Acrylamide Neural Stem Cells Neurogenesis Neuronal Outgrowth Animals Apoptosis Toxicology Hippocampus Rats
Zdroj:	The Journal of Toxicological Sciences. 47:467-482
ISSN:	1880-3989 0388-1350
DOI:	10.2131/jts.47.467
Popis:	Acrylamide (AA) is a neurotoxicant that causes synaptic impairment in distal axons. We previously found that developmental exposure to AA decreased proliferation of late-stage neural progenitor cells (NPCs) in the hippocampal neurogenesis of the dentate gyrus (DG) in rats. To investigate whether hippocampal neurogenesis is similarly affected by AA exposure in a general toxicity study, AA was administered to 7-week-old male rats via oral gavage at dosages of 0, 5, 10, and 20 mg/kg for 28 days. In the subgranular zone (SGZ) and granule cell layer, AA decreased the densities of doublecortin-positive
Databáze:	OpenAIRE
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