The effects of Ro 15-4513 on the behavioral actions of ethanol in an operant reaction time task and a conflict test
| Autor: | Lydia Percy, George F. Koob, Karen T. Britton |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Male
Azides Pentobarbital medicine.drug_class Clinical Biochemistry Alcohol Motor Activity Pharmacology Toxicology Biochemistry Anxiolytic Chlordiazepoxide Conflict Psychological Benzodiazepines Behavioral Neuroscience chemistry.chemical_compound Reaction Time medicine Animals Inverse agonist Biological Psychiatry Ethanol Behavior Animal Dose-Response Relationship Drug Rats Inbred Strains Rats Dose–response relationship chemistry Conditioning Operant Psychology Antagonism medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 31:757-760 |
| ISSN: | 0091-3057 |
| Popis: | Ro 15-4513, an analogue of the benzodiazepine receptor antagonist Ro 15-1788, has been reported to selectively block the anxiolytic and intoxicating properties of ethanol in rats. To examine the specificity and selectivity of this ethanol antagonism, the effects of Ro 15-4513 were tested on the actions of ethanol in an operant reaction time and conflict test in rats. The operant reaction time task involved holding down a lever for 0.25-2.0 seconds to obtain food, and animals treated with 1 g/kg of ethanol showed a significant disruption in performance. This disruptive effect was reversed by Ro 15-4513 in doses of 1.5-5.0 mg/kg. Ro 15-4513 was also tested in an operant conflict paradigm sensitive to alcohol effects. Ro 15-4513 (0, 1.5, 3.0, 6.0 mg/kg) produced a significant decrease in both punished and unpunished responding in the conflict test. Ethanol (0.75 g/kg), pentobarbital (5 mg/kg) and chlordiazepoxide (5 mg/kg) all produced a significant release of punished responding that was blocked by pretreatment with 6.0 mg/kg Ro 15-4513, but again Ro 15-4513 suppressed responding on its own at this dose. These results suggest that Ro 15-4513 has inverse agonist properties that may explain its ethanol-antagonist action. |
| Databáze: | OpenAIRE |
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