Succinoglycan dialdehyde-reinforced gelatin hydrogels with toughness and thermal stability
| Autor: | Seonmok Kim, Seunho Jung, Hyojeong Lee, Daham Jeong, Dajung Kim |
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| Rok vydání: | 2020 |
| Předmět: |
Toughness
Materials science food.ingredient Compressive Strength Cell Survival Cell Culture Techniques Biocompatible Materials 02 engineering and technology Biochemistry Gelatin Polyethylene Glycols 03 medical and health sciences food Tissue engineering Structural Biology Thermal stability Composite material Molecular Biology 030304 developmental biology 0303 health sciences Tissue Engineering Polysaccharides Bacterial Temperature Hydrogels General Medicine Dynamic mechanical analysis 021001 nanoscience & nanotechnology Compressive strength Self-healing hydrogels Drug delivery Rheology 0210 nano-technology |
| Zdroj: | International Journal of Biological Macromolecules. 149:281-289 |
| ISSN: | 0141-8130 |
| Popis: | Pure gelatin hydrogel (PG) has limited practical applications due to their thermal instability and unfavorable mechanical properties. To overcome these limitations, dually crosslinked hydrogels were developed by imparting chemical crosslinking to existing physically crosslinked gelatin hydrogel networks using succinoglycan dialdehyde (SGDA) as a macromolecular crosslinker. SGDA-reinforced gelatin hydrogels (SGDA/Gels) displayed an 11 times higher compressive stress under identical deformation strain and a 1040% improvement in storage modulus (G′) than PG. In addition, chemical crosslinking induced by SGDA increased the thermal stability of SGDA/Gels, such that they did not decompose at 60 °C, as confirmed by oscillatory temperature ramp experiments. The newly synthesized SGDA/Gels with reinforced networks and thermal stability exhibit potential for long-term use as controlled drug delivery carriers and 3D cell culture scaffolds for tissue engineering. |
| Databáze: | OpenAIRE |
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