MicroRNA-134 plasma levels before and after treatment with valproic acid for epilepsy patients
| Autor: | Sanhu Wang, Rongyong Man, Shuangxi Liu, Liming Tan, Yifeng Luo, Xiaofeng Wang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Neurology microRNA-134 Pharmacy Epileptogenesis Temporal lobe 03 medical and health sciences Epilepsy 0302 clinical medicine valproic acid Internal medicine medicine Psychiatry Valproic Acid business.industry Incidence (epidemiology) temporal lobe epilepsy medicine.disease 030104 developmental biology Oncology Biomarker (medicine) epilepsy biomarker business 030217 neurology & neurosurgery medicine.drug Research Paper |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | // Xiaofeng Wang 1 , Yifeng Luo 1 , Shuangxi Liu 2 , Liming Tan 3 , Sanhu Wang 4 and Rongyong Man 2 1 Department of Neurology, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630 China 2 Department of Neurology of the First People’s Hospital of Huaihua, affiliated to University of South China, Huaihua, Hunan 418000, China 3 Department of Pharmacy of the First People’s Hospital of Huaihua, affiliated to University of South China, Huaihua, Hunan 418000, China 4 Medical Research Center of the First People’s Hospital of Huaihua, affiliated to University of South China, Huaihua, Hunan 418000, China Correspondence to: Rongyong Man, email: rongyongman@aliyun.com Keywords: microRNA-134, valproic acid, epilepsy, biomarker, temporal lobe epilepsy Received: January 10, 2017 Accepted: June 12, 2017 Published: August 16, 2017 ABSTRACT Background: Temporal lobe epilepsy is the second most common neurological disorders characterized by recurrent spontaneous seizures. MicroRNAs play a vital role in regulating synaptic plasticity, brain development and post-transcriptional expression of proteins. In both animal models of epilepsy and human patients, miR-134, a brain-specific microRNA has recently been identified as a potential regulator of epileptogenesis. Methods: microRNA identified as targets for the actions of valproic acid (VPA) are known to have important effects in brain function. In this study, 59 new-onset epilepsy patients and 20 controls matched by sex and age were enrolled. Patients with a score 5 into the severe group. The plasma miRNA-134 level was quantitatively measured using real-time PCR. Results: Plasma miRNA-134 level in new-onset epilepsy patients was significantly up-regulated when compared with that in healthy controls, and then considerably down-regulated after oral intake of valproic acid medication. The up-regulated plasma miRNA-134 levels may be directly associated with the pathophysiology and severity of epilepsy. Conclusion: Plasma miRNA-134 in epilepsy may be considered as a potential peripheral biomarker that responds to the incidence of epilepsy and associates with use of anti-epilepsy drugs. |
| Databáze: | OpenAIRE |
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