Patient Characteristics and Concerns about Drug Allergy: A Report from the United States Drug Allergy Registry
| Autor: | Kimberly G. Blumenthal, Tyler Harkness, Elizabeth J. Phillips, Allison Ramsey, Aleena Banerji, Upeka Samarakoon, Cosby Stone, Xiaoqing Fu, David A. Khan, Iris Otani, Carlos A. Camargo, Yuqing Zhang, Karen Donelan, Christian M. Mancini, Catherine M. Ahola, Allen D. Judd, Weaam Arman, Elizabeth Phillips, Kristina Williams, Ronald Eugene Osea, S. Shahzad Mustafa, Holly Blue, Autumn Guyer, David Khan |
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| Rok vydání: | 2020 |
| Předmět: |
Drug
Male medicine.medical_specialty Allergy media_common.quotation_subject Drug allergy Penicillins Drug Hypersensitivity 03 medical and health sciences 0302 clinical medicine Quality of life Internal medicine medicine Immunology and Allergy Humans 030212 general & internal medicine Longitudinal Studies Prospective Studies Registries media_common Angioedema business.industry Odds ratio Middle Aged medicine.disease Rash United States Anti-Bacterial Agents 030228 respiratory system Itching Female medicine.symptom business |
| Zdroj: | The journal of allergy and clinical immunology. In practice. 8(9) |
| ISSN: | 2213-2201 |
| Popis: | Background Drug allergy is frequently reported, but uncommonly confirmed with diagnostic testing. Although drug allergy assessments can improve clinical care, patient concerns may impact the optimal diagnostic approach and/or the clinical effectiveness of diagnostic testing. Objective To assess drug allergy patient concerns. Methods Using data from a multisite, prospective longitudinal cohort study, the United States Drug Allergy Registry (January 16, 2019, to January 24, 2020), we determined patient self-reported characteristics and qualitatively coded free-text patient concerns about their drug allergy/allergies. We assessed associations between patient characteristics and drug allergy concerns using multinomial logistic regression models. Results Of 592 patients (mean age, 49 [standard deviation, 17] years, 74% female, 88% white), the most commonly reported drug allergies were penicillins (78%), cephalosporins (12%), and sulfonamides (12%) with common reactions of rash (62%), hives (54%), itching (48%), flushing or facial redness (28%), and swelling or angioedema (24%). Patient concerns, coded from free text, were optimal medication use (41%), no concern (17%), allergic reaction (14%), diagnosis (12%), and severe allergic reaction (12%). Using multinomial regression, the presence of drug allergy concerns increased with greater age, higher number of reported drug reactions, more antibiotic use, and certain reaction symptoms, most notably mouth or palate itching. Female sex was associated with increased severe allergic reaction concern. Poorer general and mental health was associated with increased allergic reaction concern. Conclusion Patients with drug allergy were concerned about their options for medical treatment, having an allergic reaction, and receiving clarity about their diagnosis. Capturing and addressing patient concerns may improve the approach to patients with drug allergy and/or the effectiveness of drug allergy testing. |
| Databáze: | OpenAIRE |
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