A Sentinel Platform to Evaluate Influenza Vaccine Effectiveness and New Variant Circulation, Canada 2010–2011 Season
| Autor: | Suzana Sabaiduc, Natasha S. Crowcroft, Kevin Fonseca, Jonathan B. Gubbay, Jennifer L. Gardy, Yan Li, Martin Petric, Naveed Z. Janjua, Nathalie Bastien, Anne-Luise Winter, Gaston De Serres, Mel Krajden, James A. Dickinson, Monique Douville Fradet, Hugues Charest, Danuta M. Skowronski |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Microbiology (medical) Canada Adolescent Influenza vaccine Orthomyxoviridae Hemagglutinin Glycoproteins Influenza Virus Real-Time Polymerase Chain Reaction medicine.disease_cause Young Adult Nasopharynx Influenza Human Influenza A virus medicine Humans Child Aged Aged 80 and over Hemagglutination assay biology Reverse Transcriptase Polymerase Chain Reaction business.industry Influenza A Virus H3N2 Subtype Influenzavirus B Infant Newborn Infant virus diseases Outbreak Sequence Analysis DNA Odds ratio Hemagglutination Inhibition Tests Middle Aged biology.organism_classification Virology Vaccination Infectious Diseases Influenza Vaccines Child Preschool Female business Sentinel Surveillance |
| Zdroj: | Clinical Infectious Diseases. 55:332-342 |
| ISSN: | 1537-6591 1058-4838 |
| DOI: | 10.1093/cid/cis431 |
| Popis: | Background. During the 2010–2011 winter, a large number of outbreaks due to influenza A/H3N2 at longterm care facilities, including higher-than-expected attack rates among vaccinated staff, were reported in some regions of Canada. Interim analysis from the community-based sentinel surveillance system showed circulating H3N2 variants and suboptimal vaccine effectiveness (VE), assessed here for the entire season’s data set. Methods. Nasal/nasopharyngeal swabs and epidemiologic details were collected from patients presenting to sentinel sites within 7 days of onset of influenza-like illness. Cases tested positive for influenza by real-time reverse-transcription polymerase chain reaction; controls tested negative. Odds ratios for medically attended, laboratory-confirmed influenza in vaccinated vs nonvaccinated participants were used to derive adjusted VE. Viruses were characterized by hemagglutination inhibition (HI), and the hemagglutinin genes of a subset were sequenced to explore vaccine relatedness. Results. Final 2010–2011 VE analysis included 1718 participants (half aged 20–49 years), 93 with A(H1N1) pdm09, 408 with A/H3N2, and 199 with influenza B. Among adults aged 20–49 years, adjusted VE was 65% (95% confidence interval [CI], 8%–87%) for A(H1N1)pdm09 and 66% (95% CI, 10%–87%) for influenza B. Vaccine effectiveness was substantially lower for A/H3N2, at 39% (95% CI, 0%–63%). Phylogenetic analysis identified 2 circulating H3N2 variant clades, A/HongKong/2121/2010 (87%) and A/Victoria/208/2009 (11%), bearing multiple amino acid substitutions at antigenic sites (12 and 8, respectively) compared with the H3N2 vaccine component used in Canada (A/Victoria/210/2009[NYMC X-187]). However, HI characterized all H3N2 isolates as well matched to the vaccine. Conclusions. Public health observations of increased facility H3N2 outbreaks were consistent with the sentinel network’s detection of genetic variants and suboptimal VE but not with conventional HI characterization. We highlight the utilityof a multicomponent sentinel surveillance platform that incorporates genotypic, phenotypic, and epidemiologic indicators into the assessment of influenza virus, new variant circulation, vaccine relatedness, and VE. |
| Databáze: | OpenAIRE |
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