Níveis séricos periféricos e mesentéricos de CEA e CA 242, estadiamento e variáveis histopatológicas no adenocarcinoma colorretal
| Autor: | Delcio Matos, Su Bong Kim, Luís Cesar Fernandes, Mauro Lamelas Cardoso |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology endocrine system diseases Colon Colorectal cancer Prognóstico Rectum Adenocarcinoma Gastroenterology Young Adult Internal medicine medicine Humans Neoplasm Antigens Tumor-Associated Carbohydrate Neoplasm Invasiveness neoplasms Mesenteric arteries Aged Neoplasm Staging Retrospective Studies Aged 80 and over business.industry Colo Middle Aged Prognosis medicine.disease digestive system diseases Reto Carcinoembryonic Antigen Mesenteric Arteries Peripheral Marcadores Biológicos de Tumor medicine.anatomical_structure Lymphatic system Tumor Markers Biological CA 242 Female Surgery Colorectal Neoplasms business |
| Zdroj: | Acta Cirurgica Brasileira, Volume: 24, Issue: 5, Pages: 405-410, Published: OCT 2009 Acta Cirúrgica Brasileira v.24 n.5 2009 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC |
| ISSN: | 0102-8650 |
| Popis: | PURPOSE: To compare histopathological variables and staging in colorectal adenocarcinoma cases with CEA and CA 242 in peripheral and mesenteric blood. METHODS: In 169 individuals underwent surgery for colorectal cancer, CEA and CA 242 were analyzed and compared to mesenteric and peripheral blood and correlated with macroscopic tumor's morphology and size, degree of cell differentiation, venous, neural and lymphatic involvement and TNM classification. RESULTS: There was a difference between the mesenteric (M) and peripheral (P) serum levels of CEA (p=0.020). Higher levels of markers were correlated with venous invasion CEA (P) p=0.013, CEA (M) p=0.05, CA 242 (M) p=0.005 and CA 242 (P) p=0.038; with advanced staging CEA (P) < CEA (M) (p < 0.05); CA 242 (P) < CA 242 (M) (p < 0.05); and with greater dimensions CEA (P) < CEA (M) (p < 0.001); CA 242 (P) < CA 242 (M) (p < 0.001). CA 242 became higher with neural invasion (P): p=0.014, (M): p=0.003). CONCLUSIONS: There were higher mesenteric than peripheral levels of CEA. Both mesenteric and peripheral levels of CEA and CA 242 were higher in neoplasm with venous involvement, greater diameter and advanced stages. There was a correlation between CA 242 and neural invasion. OBJETIVO: Comparar variáveis histopatológicas e graus de estadiamento do adenocarcinoma colorretal com níveis sanguíneos periféricos e mesentéricos de CEA e CA-242. MÉTODOS: Em 169 doentes submetidos ao tratamento cirúrgico por adenocarcinoma colorretal, CEA e CA-242 foram analisados e comparados quanto aos níveis sanguíneos periféricos e mesentéricos e correlacionados com o tamanho e a morfologia macroscópica do tumor, grau de diferenciação celular, invasões venosa, linfática, neural e a classificação TNM. RESULTADOS: Verificou-se diferença significante entre o nível sérico mesentérico e periférico de CEA (p= 0,02). Níveis séricos mais elevados dos marcadores foram observados e correlacionados com invasão venosa, CEA (P) p=0,013, CEA(M), p=0,05, CA-242 (M) p=0,005 e CA-242 (P) p=0,038. Grau de estadiamento TNM avançado foi associado com CEA(P) < CEA(M) p |
| Databáze: | OpenAIRE |
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