Changes in Event-Related Desynchronization and Synchronization during the Auditory Oddball Task in Schizophrenia Patients
| Autor: | Katsumi Nakamura, Yuji Higashi, Shinichiro Kamiya, Toshiro Fujimoto, Kouzou Takeuchi, Toshiyo Tamura, Eiichi Okumura, Masaki Sekine, Toshiaki Otsubo, Miwa Tsuji, Atsushi Kodabashi, Hiroaki Tanaka, Susumu Shimooki |
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| Rok vydání: | 2011 |
| Předmět: |
event-related synchronization
medicine.diagnostic_test Auditory oddball Alpha (ethology) Magnetoencephalography oddball task Electroencephalography medicine.disease Article P300 schizophrenia medicine.anatomical_structure Schizophrenia medicine Radiology Nuclear Medicine and imaging Neurology (clinical) Psychology Occipital lobe Neuroscience Oddball paradigm Anterior cingulate cortex event-related desynchronization |
| Zdroj: | The Open Neuroimaging Journal |
| ISSN: | 1874-4400 |
| Popis: | Objective: We studied differences in the spatiotemporal dynamics of cortical oscillation across brain regions of patients with schizophrenia and normal subjects during the auditory oddball task using magnetoencephalography (MEG) and electroencephalography (EEG). Methods: Ten right-handed male schizophrenia patients were studied. We used a newly developed adaptive spatial filtering algorithm optimized for robust source time-frequency reconstruction of MEG and EEG data, and obtained consecutive images in functional maps of event-related desynchronization (ERD) and synchronization (ERS) in theta, lower alpha (8-10 Hz), upper alpha (10-13 Hz), and beta bands. Results: Beta ERD power at 750-1000 ms in patients was significantly increased in large right upper temporal and parietal regions and small upper portions of bilateral dorsal frontal and dorsal-medial parietal regions. Theta ERS power in schizophrenic patients during the oddball task was significantly increased in the left temporal pole at 250-500 ms, and was significantly increased in dorsal, medial frontal, and anterior portions of the anterior cingulate cortex in both hemispheres, and the left portion of lateral temporal regions at 500-750 ms, compared to the control group (family-wise error correction p |
| Databáze: | OpenAIRE |
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