Regional lung blood flow and ventilation in upright humans studied with quantitative SPECT
| Autor: | Sven Nyrén, Alejandro Sanchez-Crespo, Robb W. Glenny, Blazej Neradilek, Johan Petersson, Margareta Mure, Hans Jacobsson, Dag Linnarsson, Malin Rohdin, Stig A. Larsson, Sten G. E. Lindahl, Nayak L. Polissar |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Pulmonary Circulation Supine position Physiology Posture Hemodynamics Single-photon emission computed tomography Young Adult medicine Humans Respiratory system Lung Tomography Emission-Computed Single-Photon medicine.diagnostic_test business.industry General Neuroscience digestive oral and skin physiology Blood flow medicine.anatomical_structure Regional Blood Flow Anesthesia Linear Models Respiratory Mechanics Breathing Female business Perfusion |
| Zdroj: | Respiratory Physiology & Neurobiology. 166:54-60 |
| ISSN: | 1569-9048 |
| DOI: | 10.1016/j.resp.2009.01.008 |
| Popis: | We used quantitative Single Photon Emission Computed Tomography (SPECT) to study the effect of the upright posture on regional lung blood flow and ventilation. Nine (upright) plus seven (prone and supine) healthy volunteers were studied awake, breathing spontaneously. Regional blood flow and ventilation were marked in sitting upright, supine and prone postures using (113m)In-labeled macroaggregates and inhaled Technegas ((99m)Tc); both remain fixed in the lung after administration. All images were obtained while supine. In comparison with horizontal postures, both blood flow and ventilation were greater in caudal regions when upright. The redistribution was greater for blood flow than for ventilation, resulting in decreasing ventilation-to-perfusion ratios down the lung when upright. We conclude that gravity redistributes regional blood flow and ventilation in the upright posture, while the influence is much less in the supine and prone postures. |
| Databáze: | OpenAIRE |
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