Reduced-antigen-content-diphtheria-tetanus-acellular-pertussis and inactivated polio vaccine as a booster for adolescents 10 to 14 years of age
| Autor: | Marcela Potin, Sofía Navarro, Ricardo Rüttimann, José Ussher, Joanne Wolter, Lode Schuerman, Rodrigo Vergara, Miguel Tregnaghi |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adolescent
education Immunization Secondary Booster dose Diphtheria-Tetanus-acellular Pertussis Vaccines behavioral disciplines and activities complex mixtures Antigen Double-Blind Method mental disorders medicine Humans Vaccines Combined Child Whooping cough Analysis of Variance Reactogenicity Tetanus business.industry Diphtheria social sciences medicine.disease Poliomyelitis Vaccination Poliovirus Vaccine Inactivated Pediatrics Perinatology and Child Health Immunology Antibody Formation Safety business |
| Zdroj: | European journal of pediatrics. 164(6) |
| ISSN: | 0340-6199 |
| Popis: | High rates of pertussis disease in adolescents suggest that additional boosting against pertussis would be beneficial. A combined acellular-pertussis-containing booster vaccine (dTpa-IPV; Boostrixtrade mark Polio, n =440) was compared to separately administered dTpa (Boostrixtrade mark) and inactivated polio virus (IPV; Imovax Polio((R)), n =219), and to DTPa-IPV (Infanrixtrade mark IPV, n =111) vaccine in a partially blind, randomised controlled trial in 10-14 year olds. One month after vaccination, seroprotection/seropositivity rates for all antigens were similar for all groups. Although pertussis and diphtheria antibody geometric mean antibody concentrations were higher after DTPa-IPV, all subjects had protective antibodies against diphtheria, tetanus and polio, and at least 97% had a vaccine response to pertussis antigens. Reactogenicity of dTpa-IPV was comparable to dTpa + IPV, but dTpa-IPV was generally better tolerated than DTPa-IPV.The combined reduced-antigen-content-diphtheria-tetanus-acellular-pertussis and IPV vaccine is immunogenic and well tolerated when administered to adolescents and could be used to improve the control of pertussis disease in this age group. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink