3D Cytocompatible Composites of PCL/magnetite

Autor: Díaz, Esperanza, M<, sup>, a<, Valle, Blanca, Ribeiro, Sylvie, Lanceros-Mendez, Senentxu, Barandiarán, José Manuel
Přispěvatelé: Universidade do Minho
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Materials science
magnetite
in vitro degradation
Ciências Naturais::Ciências Físicas
Magnetism
Ciências Físicas [Ciências Naturais]
Nanoparticle
02 engineering and technology
010402 general chemistry
01 natural sciences
lcsh:Technology
Article
Gel permeation chromatography
chemistry.chemical_compound
pcl
General Materials Science
Bone regeneration
lcsh:Microscopy
Magnetite
lcsh:QC120-168.85
Science & Technology
lcsh:QH201-278.5
lcsh:T
Adhesion
021001 nanoscience & nanotechnology
0104 chemical sciences
chemistry
Chemical engineering
PCL
lcsh:TA1-2040
scaffolds
magnetism
Polycaprolactone
cytotoxicity
lcsh:Descriptive and experimental mechanics
lcsh:Electrical engineering. Electronics. Nuclear engineering
Absorption (chemistry)
0210 nano-technology
lcsh:Engineering (General). Civil engineering (General)
lcsh:TK1-9971
Zdroj: Materials, Vol 12, Iss 23, p 3843 (2019)
Materials
Volume 12
Issue 23
Addi. Archivo Digital para la Docencia y la Investigación
instname
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
ISSN: 1996-1944
Popis: A study of Magnetite (Fe3O4) as a suitable matrix for the improved adhesion and proliferation of MC3T3-E1 pre-osteoblast cells in bone regeneration is presented. Biodegradable and magnetic polycaprolactone (PCL)/magnetite (Fe3O4) scaffolds, which were fabricated by Thermally Induced Phase Separation, are likewise analyzed. Various techniques are used to investigate in vitro degradation at 37 °C, over 104 weeks, in a phosphate buffered saline (PBS) solution. Magnetic measurements that were performed at physiological temperature (310 K) indicated that degradation neither modified the nature nor the distribution of the magnetite nanoparticles. The coercive field strength of the porous matrices demonstrated ferromagnetic behavior and the probable presence of particle interactions. The added nanoparticles facilitated the absorption of PBS, with no considerable increase in matrix degradation rates, as shown by the Gel Permeation Chromatography (GPC) results for Mw, Mn, and I. There was no collapse of the scaffold structures that maintained their structural integrity. Their suitability for bone regeneration was also supported by the absence of matrix cytotoxicity in assays, even after additions of up to 20% magnetite.
This work was supported by the Spanish Ministry of Economy and Competitiveness (MINECO) through the project MAT2016-76039-C4-3-R (AEI/FEDER, UE) and from the Basque Government Industry Department under the ELKARTEK, HAZITEK and PIBA programs. Supported by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Funding UID/FIS/04650/2013, project POCI-01-0145-FEDER-028237 and grant SFRH/BD/111478/2015 (S.R.) is acknowledged.
Technical and human support provided by SGIker (UPV/EHU, MICINN, GV/EJ, ERDF and ESF) is gratefully appreciated. The authors acknowledge funding by the Spanish Ministry of Economy and Competitiveness (MINECO) through the project MAT2016-76039-C4-3-R (AEI/FEDER, UE) and from the Basque Government Industry and Education Department under the ELKARTEK and HAZITEK and PIBA (PIBA-2018-06) programs. Supported by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Funding UID/FIS/04650/2013, project POCI-01-0145-FEDER-028237 and grant SFRH/BD/111478/2015 (S.R.) is acknowledged.
Databáze: OpenAIRE
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