A Structural Analysis of the FDA Green Book-Approved Veterinary Drugs and Roles in Human Medicine
| Autor: | Kevin A. Scott, Bradey A R Stuart, Bailey C Bellaire, Michael Wilcox, Christopher M Marshall, Jon T. Njardarson, Philip B. Cox, M Haziq Qureshi |
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| Rok vydání: | 2020 |
| Předmět: |
Drug
medicine.medical_specialty Insecticides Veterinary Drugs Antifungal Agents media_common.quotation_subject Anti-Inflammatory Agents Context (language use) 01 natural sciences Small Molecule Libraries 03 medical and health sciences Cytochrome P-450 Enzyme System Drug Discovery Human medicine medicine Drug approval Animals Humans Medical physics Drug Approval 030304 developmental biology media_common Anesthetics 0303 health sciences Antiparasitic Agents Chemistry United States Food and Drug Administration United States 0104 chemical sciences Structure and function Anti-Bacterial Agents 010404 medicinal & biomolecular chemistry Molecular Medicine |
| Zdroj: | Journal of medicinal chemistry. 63(24) |
| ISSN: | 1520-4804 |
| Popis: | The FDA Green Book is a list of all drug products that have been approved by the FDA for use in veterinary medicine. The Green Book, as published, lacks structural information corresponding to approved drugs. To address this gap, we have compiled the structural data for all FDA Green Book drugs approved through the end of 2019. Herein we discuss the relevance of this data set to human drugs in the context of structural classes and physicochemical properties. Analysis reveals that physicochemical properties are highly optimized and consistent with a high probability of favorable drug metabolism and pharmacokinetic properties, including good oral bioavailability for most compounds. We provide a detailed analysis of this data set organized on the basis of structure and function. Slightly over half (51%) of vet drugs are also approved in human medicine. Combination drugs are biologics are also discussed. |
| Databáze: | OpenAIRE |
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