Effects of a New Calcium Channel Blocker, Azelnidipine, on Systemic Hemodynamics and Renal Sympathetic Nerve Activity in Spontaneously Hypertensive Rats
| Autor: | Hideyasu Kiyomoto, Yoshihide Fujisawa, Shoji Kimura, Guang Ping Sun, Akira Nishiyama, Takatomi Shokoji, Matlubur Rahman, Youichi Abe, Yu Yan Fan, Masakazu Kohno |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Nitroprusside Dihydropyridines medicine.medical_specialty Mean arterial pressure Sympathetic Nervous System Physiology medicine.drug_class Vasodilator Agents Azelnidipine Calcium channel blocker Baroreflex Kidney Phenylephrine Rats Inbred SHR Internal medicine Internal Medicine medicine Animals Vasoconstrictor Agents Amlodipine business.industry Hemodynamics Dihydropyridine Calcium Channel Blockers Rats Blood pressure Endocrinology Cardiology and Cardiovascular Medicine business Azetidinecarboxylic Acid medicine.drug |
| Zdroj: | Hypertension Research. 28:1017-1023 |
| ISSN: | 1348-4214 0916-9636 |
| DOI: | 10.1291/hypres.28.1017 |
| Popis: | Antihypertensive treatment with dihydropyridine calcium channel blockers elicits sympathetic nerve activation, which may contribute to cardiovascular events. However, recent clinical studies showed that treatment with azelnidipine, a new dihydropyridine calcium channel blocker, significantly reduced blood pressure in hypertensive patients while either maintaining or actually decreasing heart rate (HR). In this study, we examined the effects of azelnidipine and amlodipine on systemic hemodynamics and renal sympathetic nerve activity (RSNA) in anesthetized spontaneously hypertensive rats (SHR). We also examined the effects of these agents on baroreflex functions by infusing phenylephrine (30 microg/kg/min, i.v.) and sodium nitroprusside (10 microg/kg/min, i.v.) into azelnidipine- or amlodipine-treated SHR. Fifty min after administration of azelnidipine (10 microg/kg/min for 10 min, i.v.), mean arterial pressure (MAP) significantly decreased from 153+/-5 to 122+/-5 mmHg; however, HR and integrated RSNA did not change significantly (from 352+/-9 to 353+/-10 beats/ min and 115+/-5% of baseline, respectively). Infusion of amlodipine (50 microg/kg/min for 10 min) elicited similar effects on MAP (from 152+/-5 to 120+/-4 mmHg). However, amlodipine significantly increased HR (from 351+/-9 to 375+/-11 beats/min) and integrated RSNA (165+/-5% of baseline). Analyses of baroreflex function curves revealed that azelnidipine-treated rats showed a smaller baroreflex function than amlodipine-treated rats (p |
| Databáze: | OpenAIRE |
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