Virus related acute pancreatitis and virus superinfection in the 'Dual disease' model of acute pancreatitis and SARS-Co-V2 infection: A multicentre prospective study
| Autor: | Jayanta Samanta, Soumya Jagannath Mahapatra, Naveen Kumar, Anshuman Elhence, Jahnvi Dhar, Anany Gupta, Anugrah Dhooria, Ashish Bhalla, Manya Prasad, Aritra Das, Raju Sharma, Rakesh Kochhar, Pramod K. Garg, Aditya Vikram Pachisia, Goverdhan Dutt Puri, Jatin Yegurla, Manas Vaishnav, Pramod Kumar Garg, Rahul Sethia, Rajat Bansal, Randeep Rana, Rithvik Golla, Sagnik Biswas, Sandeep Kumar Mundhra, Samagra Agarwal, Shubham Prasad |
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| Rok vydání: | 2021 |
| Předmět: |
Hepatology
SARS-CoV-2 viruses Endocrinology Diabetes and Metabolism fungi Gastroenterology virus diseases COVID-19 Article Acute pancreatitis body regions Coronavirus Virus induced pancreatitis Pancreatitis Chronic Superinfection Acute Disease Organ failure Humans Prospective Studies skin and connective tissue diseases |
| Zdroj: | Pancreatology |
| ISSN: | 1424-3911 |
| Popis: | Background SARS-CoV-2 can cause acute pancreatitis (AP) and SARS-CoV-2 superinfection can occur in patients with AP during prolonged hospitalisation. Our objective was to characterize SARS-CoV-2 related AP and study the impact of SARS-CoV-2 superinfection on outcomes in AP. Methods In this multicentre prospective study, all patients with AP and SARS-CoV-2 infection between August 2020 and February 2021 were divided into two groups: SARS-CoV-2-related AP and superadded SARS-CoV-2 infection in patients with AP. The two groups were compared with each other and the whole cohort was compared with a non-COVID AP cohort. Results A total of 85 patients with SARS-CoV-2 and AP (SARS-CoV-2-related AP; n = 18 and AP with SARS-CoV-2 superadded infection; n = 67) were included during the study period. They had a higher mortality [28 (32.9%) vs. 44 (19.1%), aOR 2.8 (95% CI, 1.5–5.3)] than 230 propensity matched non-COVID AP patients. Mortality in SARS-CoV-2 and AP patients was due to critical COVID. SARS-CoV-2-related- AP (n = 18) had a higher but statistically insignificant mortality than SARS-CoV-2 superinfection in AP [8/18 (44.4%) vs 20/67 (29.8%), p = 0.24]. On multivariable analysis, infection with SARS-CoV-2 (aHR 2.3; 95% CI, 1.43.7) was a predictor of in-hospital mortality in addition to organ failure (OF) in patients with AP. Conclusion Patients with AP and SARS-CoV-2 infection had a higher mortality than matched non-COVID AP patients which was largely attributable to the severity of COVID-19. SARS-CoV-2 related AP had higher OF and in-hospital mortality. Graphical abstract Image 1 |
| Databáze: | OpenAIRE |
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