Factors and Outcomes Related to the Use of Guideline-Recommended Antibiotics in Patients With Neutropenic Fever at the Uganda Cancer Institute

Autor:	Lauren Falk, Catherine Liu, Christopher C. Moore, Johnblack Kabukye, Jackie Scala, Scott V. Adams, Warren Phipps, Bickey H Chang, Elizabeth A Gulleen, Omoding Abrahams, Riley H. Hazard
Přispěvatelé:	Internal medicine
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	sub-Saharan Africa medicine.medical_specialty medicine.drug_class Antibiotics Physical examination Major Articles 03 medical and health sciences 0302 clinical medicine Internal medicine Case fatality rate medicine 030212 general & internal medicine Prospective cohort study guideline adherence neutropenic fever Acute leukemia medicine.diagnostic_test business.industry Hazard ratio Guideline medicine.disease antimicrobial stewardship Infectious Diseases AcademicSubjects/MED00290 Oncology 030220 oncology & carcinogenesis hematologic malignancy business Febrile neutropenia
Zdroj:	Open Forum Infectious Diseases Open Forum Infectious Diseases, 8(7). Oxford University Press Gulleen, E A, Adams, S V, Chang, B H, Falk, L, Hazard, R, Kabukye, J, Scala, J, Liu, C, Phipps, W, Abrahams, O & Moore, C C 2021, ' Factors and Outcomes Related to the Use of Guideline-Recommended Antibiotics in Patients With Neutropenic Fever at the Uganda Cancer Institute ', Open Forum Infectious Diseases, vol. 8, no. 7, pp. ofab307 . https://doi.org/10.1093/ofid/ofab307
ISSN:	2328-8957
DOI:	10.1093/ofid/ofab307
Popis:	Background Neutropenic fever (NF) is associated with significant morbidity and mortality for patients receiving cancer treatment in sub-Saharan Africa (sSA). However, the antibiotic management of NF in sub-Saharan Africa has not been well described. We evaluated the timing and selection of antibiotics for patients with NF at the Uganda Cancer Institute (UCI). Methods We conducted a retrospective chart review of adults with acute leukemia admitted to UCI from 1 January 2016 to 31 May 2017, who developed NF. For each NF event, we evaluated the association of clinical presentation and demographics with antibiotic selection as well as time to both initial and guideline-recommended antibiotics. We also evaluated the association between ordered antibiotics and the in-hospital case fatality ratio (CFR). Results Forty-nine NF events occurred among 39 patients. The time to initial antibiotic order was We examined adherence to guideline-recommended antibiotics in 49 neutropenic fever episodes among adults with acute leukemia at the Uganda Cancer Institute. Guideline-recommended antibiotics were ordered in 37 (75%) events, but median time to guideline-recommended antibiotic order was 3 days.
Databáze:	OpenAIRE
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