Skeletal Muscle Mitochondrial Function and Fatigability in Older Adults
| Autor: | Sharon A. Jubrias, Kevin E. Conley, Anne B. Newman, Robert M. Boudreau, Dawn C. Mackey, Paul M. Coen, Nancy W. Glynn, Bret H. Goodpaster, Adam J. Santanasto, Eleanor M. Simonsick, Elsa S. Strotmeyer, Francesca Amati |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Aging medicine.medical_specialty Walking Quadriceps Muscle Phosphocreatine Cohort Studies chemistry.chemical_compound Adenosine Triphosphate Internal medicine medicine Humans Treadmill Fatigue Aerobic capacity Aged Aged 80 and over Adenosine Triphosphate/metabolism Age Factors Energy Metabolism/physiology Exercise Test Exercise Tolerance/physiology Fatigue/etiology Fatigue/metabolism Fatigue/physiopathology Female Mitochondria Muscle/physiology Quadriceps Muscle/metabolism Quadriceps Muscle/physiopathology Fatigability Mitochondrial function Skeletal muscle Rating of perceived exertion Exercise Tolerance business.industry Odds ratio Mitochondria Muscle Preferred walking speed medicine.anatomical_structure chemistry Physical therapy Cardiology Geriatrics and Gerontology Energy Metabolism business human activities Body mass index Research Article |
| Zdroj: | The journals of gerontology. Series A, Biological sciences and medical sciences, vol. 70, no. 11, pp. 1379-1385 |
| ISSN: | 1758-535X 1079-5006 |
| DOI: | 10.1093/gerona/glu134 |
| Popis: | Fatigability increases while the capacity for mitochondrial energy production tends to decrease significantly with age. Thus, diminished mitochondrial function may contribute to higher levels of fatigability in older adults. The relationship between fatigability and skeletal muscle mitochondrial function was examined in 30 participants aged 78.5 ± 5.0 years (47% female, 93% white), with a body mass index of 25.9 ± 2.7 kg/m(2) and usual gait-speed of 1.2 ± 0.2 m/s. Fatigability was defined using rating of perceived exertion (6-20 point Borg scale) after a 5-minute treadmill walk at 0.72 m/s. Phosphocreatine recovery in the quadriceps was measured using (31)P magnetic resonance spectroscopy and images of the quadriceps were captured to calculate quadriceps volume. ATPmax (mM ATP/s) and oxidative capacity of the quadriceps (ATPmax·Quadriceps volume) were calculated. Peak aerobic capacity (VO2peak) was measured using a modified Balke protocol. ATPmax·Quadriceps volume was associated with VO2peak and was 162.61mM ATP·mL/s lower (p = .03) in those with high (rating of perceived exertion ≥10) versus low (rating of perceived exertion ≤9) fatigability. Participants with high fatigability required a significantly higher proportion of VO2peak to walk at 0.72 m/s compared with those with low fatigability (58.7 ± 19.4% vs 44.9 ± 13.2%, p < .05). After adjustment for age and sex, higher ATPmax was associated with lower odds of having high fatigability (odds ratio: 0.34, 95% CI: 0.11-1.01, p = .05). Lower capacity for oxidative phosphorylation in the quadriceps, perhaps by contributing to lower VO2peak, is associated with higher fatigability in older adults. |
| Databáze: | OpenAIRE |
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