Oxidative stress in Strongylus spp. infected donkeys treated with piperazine citrate versus doramectin
| Autor: | Arafat Khalphallah, Enas Elmeligy, Ahmed Hafez, Khaled A.S. El-Khabaz, Hanan K. Elsayed, Rehab A. Ghandour, Abdelbaset Eweda Abdelbaset, Ashraf M. Abu-Seida, Dalia Hassan, Sara A. Bayomi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
malondialdehyde
General Veterinary biology business.industry donkeys strongylosis piperazine citrate Physiology doramectin Malondialdehyde Strongylus chemistry.chemical_compound chemistry QL1-991 biology.animal medicine Anthelmintic Doramectin Equidae Piperazine Citrate business Zoology Feces medicine.drug Whole blood |
| Zdroj: | Open Veterinary Journal, Vol 11, Iss 2, Pp 238-250 (2021) |
| ISSN: | 2218-6050 |
| Popis: | Background Parasitic infection is one of the main problems in equidae, particularly donkeys. Aim This study evaluated the oxidative stress in donkeys infected with Strongylus spp by determining the correlation between antioxidants levels; malondialdehyde (MDA), total antioxidant capacity (TAC), and the severity of parasitic infection. It also compared the therapeutic efficacy of piperazine citrate as an oral anthelmintic drug and Doramectin as an injectable one. Methods The study was conducted on 40 donkeys naturally infected with Strongylus spp. These donkeys were divided into two groups (20 donkeys each) according to treatment; One group was treated with piperazine citrate (PipTG) and the other with doramectin (DoraTG). Thorough clinical examination, hematological, biochemical, and parasitological assays were performed before (Day 0) and after treatment (Days 7, 14, 21, and 28). All data were statistically analyzed by independent-sample t-test or paired t-test. Results In both groups, mean values of MDA were significantly reduced, while those of TAC were significantly elevated after treatment on days 7, 14, 21, and 28. These significant changes were reported after treatment between PipTG and DoraTG in favor of DoraTG. Serum concentrations of MDA were significantly reduced, while those of TAC were significantly elevated for DoraTG treatment group when their values were compared with those of PipTG either on days 7, 14, 21, or 28. Significant correlations were reported in PipTG and DoraTG. Negative significant correlations were reported between fecal egg count (FEC) and each of whole blood picture indices (RBCS, Hb, and PCV), serum TAC and faecal egg count reduction percentage FECR%. A positive correlation was seen between FEC and MDA. MDA exhibited a negative correlation with both blood picture and TAC; hence, TAC was positively correlated with these blood picture indices in both PipTG and DoraTG. In PipTG, anthelmintic resistance (R) was present on days 7 and 14, while it was suspected (S) at day 21 then it was absent (N) at day 28. In DoraTG, anthelmintic resistance was suspected (S) on day 7, then it became absent (N) on days 14, 21, and 28 post therapy. Conclusion The immunological status of the infected donkeys had greatly improved after treatment. The therapeutic efficacy of injectable doramectin was more efficient than that of oral piperazine citrate in Strongylus spp. infected donkeys. |
| Databáze: | OpenAIRE |
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