Elevated liver enzymes following polytraumatic injury
| Autor: | James B Sanderlin, Jasmohan S Bajaj, William Carne, Shane McNamee, David X. Cifu, Aaron Fox |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Traumatic brain injury medicine.medical_treatment Liver Function Tests Internal medicine medicine Humans Veterans Affairs Monitoring Physiologic Retrospective Studies Rehabilitation Trauma Severity Indices medicine.diagnostic_test business.industry Multiple Trauma Retrospective cohort study Alanine Transaminase medicine.disease Polytrauma Surgery Military Personnel Liver Concomitant Brain Injuries Etiology Female Liver function tests business Follow-Up Studies |
| Zdroj: | Journal of rehabilitation research and development. 51(6) |
| ISSN: | 1938-1352 |
| Popis: | This retrospective cohort study examined the prevalence and potential risk factors for elevated liver enzymes in patients following traumatic brain injury (TBI). The participants were servicemembers with TBI admitted to the Polytrauma Rehabilitation Center (PRC) at the Hunter Holmes McGuire Department of Veterans Affairs Medical Center in Richmond, Virginia, from January 2008 through December 2011. The PRC had 207 patients during this time period, 121 of whom had a liver panel within 30 d of injury. Patients were retrospectively analyzed and placed into one of two categories based on alanine aminotransferase (ALT) values. Of the 121 subjects, 59 (49%) had an ALT of 44 IU/L or greater on their initial set of laboratories. These subjects were compared with those with an ALT of 43 IU/L or less using chi square analysis. There were no significant differences between the two groups with regards to sex, military status, race, theater, TBI mechanism, severity of TBI, or concomitant injuries. Regardless of demographics, mechanism of injury, or extent of trauma, elevated liver enzymes are common in patients admitted to the rehabilitation unit following TBI. For the majority of these patients, enzymes returned to normal with conservative management. In most cases, no specific etiology was ever defined. Further analysis will be performed to determine the most efficient way to monitor these patients so that unnecessary test are avoided and medical expenses are minimized. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|