Signal intensity, clinical activity and cross-sectional areas on MRI scans in thyroid eye disease
| Autor: | P Goddard, J Kabala, D L Fox, Richard W J Lee, M J Potts, G Herdman, E J Mayer, James Hsuan |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Eye disease Inversion recovery Severity of Illness Index Disease activity Humans Medicine Radiology Nuclear Medicine and imaging Retrospective Studies Inflammation Observer Variation Anatomy Cross-Sectional medicine.diagnostic_test business.industry Thyroid Reproducibility of Results Magnetic resonance imaging General Medicine medicine.disease Clinical disease Magnetic Resonance Imaging eye diseases Graves Ophthalmopathy medicine.anatomical_structure Oculomotor Muscles Disease Progression Female Radiology Mr images Signal intensity business Nuclear medicine |
| Zdroj: | European Journal of Radiology. 56:20-24 |
| ISSN: | 0720-048X |
| DOI: | 10.1016/j.ejrad.2005.03.027 |
| Popis: | The signal intensity from inflamed extra-ocular muscles on short tau inversion recovery (STIR)-sequence magnetic resonance imaging (MRI) is known to correlate with clinical scores of thyroid eye disease (TED) severity. Twenty-one patients who had undergone repeated MRI scanning for TED were studied retrospectively. Signal intensity of extra-ocular muscles (from STIR-sequence MRI) and cross-sectional area (from STIR and T1 MRI) were correlated with Mourits' clinical activity score (CAS). The area of highest signal intensity within the most inflamed extra-ocular muscle, and the average cross-sectional signal intensity of the most inflamed extra-ocular muscle reliably correlated with CAS, and this was maintained as disease activity changed over time. In contrast, isolated measures of muscle cross-sectional area did not correlate with CAS. The extra-ocular muscle cross-sectional area calculated from STIR-sequence MR images was greater than that measured on T1 images. This suggests that muscle area from STIR-sequence MRI may also detect peri-muscular inflammation. We conclude that the peak signal intensity from the most inflamed extra-ocular muscle remains the most reliable correlate of clinical disease activity obtained from these images. STIR-sequence MRI scans provide a number of useful measures of disease activity in TED. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect