Non-invasive Assessment of Liver Fibrosis with ElastPQ: Comparison with Transient Elastography and Serologic Fibrosis Marker Tests, and Correlation with Liver Pathology Results
| Autor: | Jeong Eun Lee, Kyung-Hee Kim, Kyung Sook Shin, In Sang Song, Sun Kyoung You, June-Sik Cho, Ji Hye Min, Kwang Sik Cheon |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Cirrhosis Acoustics and Ultrasonics Biopsy Biophysics Severity of Illness Index Gastroenterology 030218 nuclear medicine & medical imaging Young Adult 03 medical and health sciences 0302 clinical medicine Fibrosis Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Aged Retrospective Studies Aged 80 and over Radiological and Ultrasound Technology medicine.diagnostic_test Receiver operating characteristic business.industry Ultrasound Reproducibility of Results Middle Aged medicine.disease Liver Liver biopsy Elasticity Imaging Techniques Feasibility Studies Female 030211 gastroenterology & hepatology Hepatic fibrosis business Transient elastography Biomarkers |
| Zdroj: | Ultrasound in Medicine & Biology. 43:2515-2521 |
| ISSN: | 0301-5629 |
| DOI: | 10.1016/j.ultrasmedbio.2017.07.008 |
| Popis: | We investigated the feasibility of using ultrasound shear wave elastography point quantification (ElastPQ) for liver fibrosis staging and compared it with other non-invasive tools with respect to efficacy in liver stiffness measurement. A total of 106 patients who underwent liver stiffness measurements, using ElastPQ and biochemical investigations, before parenchymal liver biopsy or surgery were included. Among these, 51 also underwent transient elastography (TE). Correlations of ElastPQ, TE and aspartate aminotransferase-to-platelet ratio index (APRI) with histopathological findings (as the reference standard) were determined using Spearman's correlation coefficient. The diagnostic performance of ElastPQ, TE and APRI was evaluated using receiver operating characteristic (ROC) curve analysis. ElastPQ had good diagnostic accuracy in identifying each liver fibrosis stage, with an area under the ROC curve (AUC) of 0.810 to 0.864. Stiffness values obtained using ElastPQ, TE and APRI were significantly positively correlated (r = 0.686, r = 0.732 and r = 0.454, respectively) with histologic fibrosis staging (p < 0.001). According to the AUC for the diagnosis of significant fibrosis (≥F2) and cirrhosis (=F4), ElastPQ had better diagnostic accuracy (AUC = 0.929 and 0.834, respectively) than APRI (AUC = 0.656 and 0.618, respectively) (p < 0.05), and was similar to TE (AUC = 0.915 and 0.879, respectively). ElastPQ is a promising ultrasound-based imaging technique for evaluation of liver fibrosis, with a diagnostic accuracy comparable to that of TE. |
| Databáze: | OpenAIRE |
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