Hippocampal volume reduction is associated with direct measure of insulin resistance in adults
| Autor: | Natalie L. Rasgon, Sophia Frangou, Alison Myoraku, Katie Watson, Amirhossein Modabbernia, Mathilde Antoniades, Thalia K. Robakis, Shalaila S. Haas, Fahim Abbasi |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Blood Glucose
medicine.medical_specialty business.industry General Neuroscience Leptin General Medicine Hippocampal formation medicine.disease Hippocampus Fasting insulin Article Direct measure Body Mass Index Insulin resistance Endocrinology Internal medicine medicine Hippocampal volume Humans Insulin Female Risk factor Insulin Resistance business Body mass index |
| Zdroj: | Neurosci Res |
| Popis: | Hippocampal integrity is highly susceptible to metabolic dysfunction, yet its mechanisms are not well defined. We studied 126 healthy individuals aged 23–61 years. Insulin resistance (IR) was quantified by measuring steady-state plasma glucose (SSPG) concentration during the insulin suppression test. Body mass index (BMI), adiposity, fasting insulin, glucose, leptin as well as structural neuroimaing with automatic hippocampal subfield segmentation were performed. Data analysis using unsupervised machine learning (k-means clustering) identified two subgroups reflecting a pattern of more pronounced hippocampal volume reduction being concurrently associated with greater adiposity and insulin resistance; the hippocampal volume reductions were uniform across subfields. Individuals in the most deviant subgroup were predominantly women (79 versus 42 %) with higher BMI [27.9 (2.5) versus 30.5 (4.6) kg/m2], IR (SSPG concentration, [156 (61) versus 123 (70) mg/dL] and leptinemia [21.7 (17.0) versus 44.5 (30.4) μg/L]. The use of person-based modeling in healthy individuals suggests that adiposity, insulin resistance and compromised structural hippocampal integrity behave as a composite phenotype; female sex emerged as risk factor for this phenotype. |
| Databáze: | OpenAIRE |
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