Fast X-Ray Luminescence Computed Tomography Imaging
| Autor: | Hongkai Wang, Xin Liu, Qimei Liao |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Physics
Phantoms Imaging business.industry Optical Imaging Biomedical Engineering Field of view Iterative reconstruction Imaging phantom Optics Compressed sensing Image Processing Computer-Assisted Molecular imaging Tomography X-Ray Computed business Luminescence Nuclear medicine Image resolution Beam (structure) |
| Zdroj: | IEEE Transactions on Biomedical Engineering. 61:1621-1627 |
| ISSN: | 1558-2531 0018-9294 |
| DOI: | 10.1109/tbme.2013.2294633 |
| Popis: | X-ray luminescence computed tomography (XLCT) opens new possibilities to perform molecular imaging with X-ray. However, challenges remain in dynamic XLCT imaging, where short scan time, good spatial resolution, and whole-body field of view should be considered simultaneously. In this paper, by the use of a single-view XLCT reconstruction method based on a compressive sensing (CS) technique, incorporating a cone beam XLCT imaging system, we implement fast 3-D XLCT imaging. To evaluate the performance of the method, two types of phantom experiments were performed based on a cone beam XLCT imaging system. In Case 1, one tube filled with the X-ray-excitable nanophosphor (Gd $_{2}$ O $_{3}$ :Eu $^{3+}$ ) was immerged in different positions in the phantom to evaluate the effect of the source position on single-view XLCT reconstruction accuracy. In Case 2, two tubes filled with Gd $_{2}$ O $_{3}$ :Eu $^{3+}$ were immerged in different heights in the phantom to evaluate the whole-body imaging performance of single-view XLCT reconstruction. The experimental results indicated that the tubes used in previous phantom experiments can be resolved from single-view XCLT reconstruction images. The location error is less than 1.2 mm. In addition, since only one view data are needed to implement 3-D XLCT imaging, the acquisition time can be greatly reduced (∼1 frame/s) compared with previous XLCT systems. Hence, the technique is suited for imaging the fast distribution of the X-ray-excitable nanophosphors within a biological object. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|