Toxicity of Insulin Administered Chronically to Human Eye In Vivo
| Autor: | Anne Turner-Henson, Joycelyn A. Atchison, Jimmy D. Bartlett, Karan P. Singh, Dennis J. Pillion, Todd G. Slusser |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Blood Glucose Male Intraocular pressure Visual acuity genetic structures medicine.medical_treatment Visual Acuity Eye Placebo Double-Blind Method Diabetes mellitus Cornea Humans Insulin Medicine Pharmacology (medical) Prospective Studies Saline Intraocular Pressure Pharmacology business.industry medicine.disease eye diseases Ophthalmology medicine.anatomical_structure Anesthesia Toxicity Female sense organs Ophthalmic Solutions medicine.symptom business |
| Zdroj: | Journal of Ocular Pharmacology and Therapeutics. 10:101-107 |
| ISSN: | 1557-7732 1080-7683 |
| Popis: | Insulin administered in eyedrop from with a surfactant agent has been shown to be clinically effective in treating diabetes in animal models. Concentrations of insulin as high as 100 U/ml in saline were shown to produce no detectable clinical toxicity to human eyes in single-dose administration. We sought to investigate the local toxicity of insulin in human eyes during long-term, multidose administration. A prospective, randomized, placebo controlled, double-masked study was conducted involving eight healthy volunteers. Subjects were given 50 microliters sterile saline containing 100 U/ml crystalline porcine insulin randomized to one eye and 50 microliters placebo (sterile saline) to the fellow eye administered twice daily for 8 weeks. Subjective ocular irritation and visual acuity and objective assessment of the eyelids, conjunctiva, cornea, anterior chamber, crystalline lens, pupil size, and intraocular pressure were evaluated. Blood D-glucose levels were monitored to assess glycemic levels. There was no statistically significant difference (p > 0.05) observed between insulin-treated and placebo-treated eyes. Eyedrops containing insulin were subjectively as comfortable and objectively as clinically innocuous as sterile saline alone. The results of this study demonstrate that insulin (100 U/ml) in saline is nontoxic to the human eye after long-term, multi-dose exposure. Topical administration of insulin combined with an absorption-promoting agent may be a practical and feasible alternative to multiple daily subcutaneous injections or implanted pump devices currently used in the long-term treatment of diabetes mellitus if a nonirritating absorption-promoting agent can be identified.(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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