Mechanism of thrombosis caused by sclerotherapy of esophageal varices using sodium tetradecyl sulphate
| Autor: | J. A. Myburgh, B. V. Mendelow, B. F. Jacobson, E. M. Hurly, R. C. Franz, P. Becker, G. L. Norman |
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| Rok vydání: | 1992 |
| Předmět: |
Blood Platelets
medicine.medical_specialty Umbilical Veins Endothelium Platelet Aggregation medicine.drug_class medicine.medical_treatment Pharmacology Esophageal and Gastric Varices Umbilical cord Sodium Tetradecyl Sulfate Esophageal varices medicine Sclerotherapy Humans Platelet Blood Coagulation business.industry Anticoagulant medicine.disease Thrombosis Sclerosing Solutions Surgery medicine.anatomical_structure Coagulation Microscopy Electron Scanning Endothelium Vascular business |
| Zdroj: | Surgical endoscopy. 6(1) |
| ISSN: | 0930-2794 |
| Popis: | The mechanism of thrombosis following intravariceal injection of sodium tetradecyl sulphate (S.T.D.) was investigated with respect to effects on the vascular endothelium, the coagulation cascade, and platelet function. Using an umbilical cord model designed to simulate blood flow over the endothelium, it was found that S.T.D. is a potent toxin for endothelial cells in that brief exposure to even low concentrations of the agent were effective in stripping endothelium over a considerable distance, exposing highly thrombogenic endothelium in the process. Effects on coagulation and platelet function were found to be dependent on concentration. Diluted S.T.D. induced a hypercoagulable state, possibly in consequence of a selective inhibition of the physiological anticoagulant, protein C, and promoted platelet aggregation. Higher concentrations inactivated the coagulation cascade and lysed platelets completely. These results suggest that intravariceal infusion of S.T.D. at considerable dilution may be at least as effective in inducing thrombosis as standard dosage, and possibly more so. |
| Databáze: | OpenAIRE |
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