Proinflammatory Cytokine IL-17 Shows a Significant Association with Helicobacter pylori Infection and Disease Severity
| Autor: | Chinthika Gunasekara, Deepaka Weerasekera, Bimalka Senevirathna, Manjula Weerasekera, Neluka Fernando, Piyumali Sandareka Arachchi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Helicobacter pylori infection Hepatology Article Subject business.industry Gastroenterology Chronic gastritis Inflammation medicine.disease Proinflammatory cytokine 03 medical and health sciences Patient population 030104 developmental biology 0302 clinical medicine Immune system Disease severity Immunology medicine lcsh:Diseases of the digestive system. Gastroenterology Interleukin 17 medicine.symptom lcsh:RC799-869 business 030215 immunology |
| Zdroj: | Gastroenterology Research and Practice, Vol 2017 (2017) |
| ISSN: | 1687-6121 |
| DOI: | 10.1155/2017/6265150 |
| Popis: | Background. The pro- and anti-inflammatory cytokines play an important role in the immune response against H. pylori infection. The proinflammatory cytokines of Th17 cells have been suggested to play a major role in H. pylori infection and resulting gastric inflammation. Objective. The objective of this study was to compare the expression of selected inflammatory cytokines (IL-10, IL-17, IL-21, IL-23, and TNF-α) in H. pylori-infected patients and healthy controls and to understand their association with H. pylori infection and disease severity. Results. The expression levels of IL-17 and IL-23 were significantly higher in H. pylori-infected patients. The expression of IL-21 was also higher in H. pylori-positive patients but there was no significant association with infection. IL-17 expression showed a significant increase with the severity of chronic gastritis. Conclusion. The proinflammatory cytokine, IL-17, shows a significant association with H. pylori infection and disease severity in a Sri Lankan dyspeptic patient population. |
| Databáze: | OpenAIRE |
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