Estrogen and Progesterone Receptor Content in Human Thyroid Disease
| Autor: | Elliot W. Strong, Celia J. Menendez-Botet, Karen H. Van Hoeven, Andrew G. Huvos |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Pathology Goiter medicine.drug_class Estrogen receptor Thyroiditis Internal medicine Follicular phase Progesterone receptor medicine Carcinoma Humans Thyroid Neoplasms business.industry Thyroid General Medicine Middle Aged medicine.disease Thyroid Diseases Carcinoma Papillary Endocrinology medicine.anatomical_structure Receptors Estrogen Estrogen Female Receptors Progesterone business |
| Zdroj: | American Journal of Clinical Pathology. 99:175-181 |
| ISSN: | 1943-7722 0002-9173 |
| Popis: | Recent studies have confirmed the presence of estrogen and progesterone receptors in many benign and malignant thyroid tumors, but their clinical significance is unclear. The estrogen and progesterone receptor content of 135 thyroid lesions was assayed prospectively from 1980 through 1986 using the dextran-coated charcoal method. The cases included 30 papillary, 13 follicular, 6 medullary, and 2 Hurthle cell carcinomas. Thirty-two follicular adenomas, 45 goiters, and 7 cases of thyroiditis also were studied. Estrogen receptor protein was positive (> or = 2 fmol/mg) in 46% of the cases, with no clear statistical predilection related to the type or size of the thyroid lesion, age, or sex. Progesterone receptor protein was positive (> or = 10 fmol/mg) in 51% of the cases, with the highest median values obtained in papillary carcinomas, particularly in male patients and women older than 50 years. Metastases at presentation, noted in 28 of 51 carcinomas, were unrelated to receptor content. Mean follow-up of 55 months in 48 patients with various carcinomas yielded 12 cases with late metastases, which were similarly unrelated to receptor content. Although estrogen receptors are commonly detectable in thyroid lesions, they have no clear relationship to presenting clinical or pathologic features or, in cases of carcinoma, to subsequent metastatic potential. The role of progesterone activity in papillary carcinoma and in goiter merits more investigation. |
| Databáze: | OpenAIRE |
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