Stachyose: One of the Active Fibroblast-proliferating Components in the Root of Rehmanniae Radix (地黃 dì huáng)
| Autor: | Ling Cheng, Patrick Kwok-Kin Lai, Clara Bik-San Lau, Cheuk-Lun Liu, Kit-Man Lau, Ping-Chung Leung, Kwok-Pui Fung, Ming-Ho To |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Ethanol
biology lcsh:R Active components Rehmanniae Radix Fibroblast proliferation lcsh:Medicine Rehmannia glutinosa biology.organism_classification High-performance liquid chromatography Stachyose chemistry.chemical_compound Verbascoside medicine.anatomical_structure Complementary and alternative medicine chemistry Biochemistry medicine Original Article Fibroblast |
| Zdroj: | Journal of Traditional and Complementary Medicine, Vol 2, Iss 3, Pp 227-234 (2012) Journal of Traditional and Complementary Medicine |
| ISSN: | 2225-4110 |
| Popis: | This study aimed to investigate and compare the fibroblast-proliferating activities of different Rehmanniae Radix (RR) samples and its chemical components using human normal fibroblast cells Hs27. Those active components were quantified in differently treated RR samples using UPLC so as to correlate activity with component content. Our results showed that dried RR aqueous extract exhibited the most potent fibroblast-proliferating activity. Stronger effect was observed when ethanol with heating was applied in the extraction process. Stachyose and verbascoside were demonstrated for their first time to exhibit significant stimulatory effects on fibroblast proliferation. However, the proliferating effect of dried RR extract did not correlate with the stachyose content, and verbascoside was not responsible for the fibroblast proliferative effect of RR since it was undetectable in all samples. In conclusion, stachyose only contributed in part to the activity of RR, suggesting that other active components might be present and yet to be found. |
| Databáze: | OpenAIRE |
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