Polysaccharide-Based Conjugates for Biomedical Applications
| Autor: | Ester Abtew, Abraham J. Domb, Konda Reddy Kunduru, Arijit Basu |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Pharmacology
chemistry.chemical_classification Tissue Engineering Chemistry Carboxylic acid Organic Chemistry Biomedical Engineering Pharmaceutical Science Biocompatible Materials Bioengineering Receptor-mediated endocytosis Polysaccharide Controlled release Biochemistry Tissue engineering Polysaccharides Solubilization Nanotechnology Biotechnology Macromolecule Conjugate |
| Zdroj: | Bioconjugate Chemistry. 26:1396-1412 |
| ISSN: | 1520-4812 1043-1802 |
| DOI: | 10.1021/acs.bioconjchem.5b00242 |
| Popis: | Polysaccharides contain different functional groups (such as hydroxyl, amino, carboxylic acid, aldehydes) that make them ideal for conjugation. They are biodegradable, biocompatible, and hydrophilic. Polysaccharide conjugates have been used in drug, gene, and macromolecule delivery, tissue engineering, and other biomedical applications. Polysaccharide conjugates have also been used primarily for solubilization and controlled release of hydrophobic moieties. The advent of nanotechnology, gene therapy, and tissue engineering influenced the way these conjugates are now used. Modern day conjugates are modulated to be thermoresponsive, pH-responsive, photoresponsive, or target-specific (receptor mediated targeting). This Review briefly introduces different polysaccharides followed by different synthetic strategies used for conjugation; finally, recent applications were compiled. |
| Databáze: | OpenAIRE |
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