Targeting Mitochondrial Singlet Oxygen Dynamics Offers New Perspectives for Effective Metabolic Therapies of Cancer
| Autor: | Mario Jolicoeur, Jorgelindo da Veiga Moreira, Laurent Schwartz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_treatment Review Mitochondrion lcsh:RC254-282 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Cytochrome c oxidase cancer singlet oxygen therapy Chemotherapy biology Singlet oxygen business.industry Cancer chemoresistance Immunotherapy medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens metabolic therapy Radiation therapy mitochondria 030104 developmental biology chemistry Oncology 030220 oncology & carcinogenesis Cancer cell biology.protein Cancer research business |
| Zdroj: | Frontiers in Oncology, Vol 10 (2020) Frontiers in Oncology |
| DOI: | 10.3389/fonc.2020.573399/full |
| Popis: | The occurrence of mitochondrial respiration has allowed evolution toward more complex and advanced life forms. However, its dysfunction is now also seen as the most probable cause of one of the biggest scourges in human health, cancer. Conventional cancer treatments such as chemotherapy, which mainly focus on disrupting the cell division process, have shown being effective in the attenuation of various cancers but also showing significant limits as well as serious sides effects. Indeed, the idea that cancer is a metabolic disease with mitochondria as the central site of the pathology is now emerging, and we provide here a review supporting this "novel" hypothesis re-actualizing past century Otto Warburg's thoughts. Our conclusion, while integrating literature, is that mitochondrial activity and, in particular, the activity of cytochrome c oxidase, complex IV of the ETC, plays a fundamental role in the effectiveness or non-effectiveness of chemotherapy, immunotherapy and probably radiotherapy treatments. We therefore propose that cancer cells mitochondrial singlet oxygen (1O2) dynamics may be an efficient target for metabolic therapy development. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|