Helicobacter pyloriin human health and disease: Mechanisms for local gastric and systemic effects
| Autor: | Cristopher Soto, Anilei Hoare, Andrew F. G. Quest, Denisse Bravo, Manuel Valenzuela |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Population Inflammation Review Disease Systemic inflammation 03 medical and health sciences Human health 0302 clinical medicine medicine Microbiome education education.field_of_study biology business.industry Disease mechanisms Gastroenterology General Medicine Helicobacter pylori bacterial infections and mycoses biology.organism_classification 030104 developmental biology Immunology 030211 gastroenterology & hepatology medicine.symptom business |
| Zdroj: | World Journal of Gastroenterology. 24:3071-3089 |
| ISSN: | 1007-9327 |
| Popis: | Helicobacter pylori (H. pylori) is present in roughly 50% of the human population worldwide and infection levels reach over 70% in developing countries. The infection has classically been associated with different gastro-intestinal diseases, but also with extra gastric diseases. Despite such associations, the bacterium frequently persists in the human host without inducing disease, and it has been suggested that H. pylori may also play a beneficial role in health. To understand how H. pylori can produce such diverse effects in the human host, several studies have focused on understanding the local and systemic effects triggered by this bacterium. One of the main mechanisms by which H. pylori is thought to damage the host is by inducing local and systemic inflammation. However, more recently, studies are beginning to focus on the effects of H. pylori and its metabolism on the gastric and intestinal microbiome. The objective of this review is to discuss how H. pylori has co-evolved with humans, how H. pylori presence is associated with positive and negative effects in human health and how inflammation and/or changes in the microbiome are associated with the observed outcomes. |
| Databáze: | OpenAIRE |
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