Stearidonic acid combined with alpha-linolenic acid improves lipemic and neurological markers in a rat model subject to a hypercaloric diet
| Autor: | María José González-Fernández, Joana Paiva Martinho, José Luis Guil-Guerrero, Narcisa M. Bandarra, Jorge Correia, Francisco Javier Alarcón, Carlos Cardoso, Paula Lopes, Rui M. Pinto, José A. M. Prates, Susana Martins, Cláudia Afonso |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
food.ingredient Clinical Biochemistry CREB 03 medical and health sciences chemistry.chemical_compound food Linseed oil Fatty Acids Omega-3 Animals Plant Oils Food science Cyclic AMP Response Element-Binding Protein 030109 nutrition & dietetics biology Tumor Necrosis Factor-alpha Chemistry alpha-Linolenic acid Fatty Acids alpha-Linolenic Acid Cell Biology Lipid Metabolism Fish oil Eicosapentaenoic acid Rats Disease Models Animal Gene Expression Regulation Diet Western Docosahexaenoic acid biology.protein Drug Therapy Combination lipids (amino acids peptides and proteins) Tumor necrosis factor alpha Stearidonic acid |
| Zdroj: | Prostaglandins, Leukotrienes and Essential Fatty Acids. 135:137-146 |
| ISSN: | 0952-3278 |
| DOI: | 10.1016/j.plefa.2018.07.010 |
| Popis: | Summary In this study, we hypothesized that terrestrial plant oils, rich in alpha linolenic acid (ALA) and stearidonic acid (SDA) relative to fish oil, rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), prevent negative effects on cardiovascular and neurological function using a rat model fed a hypercaloric diet. Results showed effects on the FA profile, namely, eicosapentaenoic, EPA, and docosahexaenoic, DHA, levels. There were also effects on neural aspects (cAMP response element-binding protein, CREB, gene expression, at least, doubled) and the pro-inflammatory/anti-inflammatory balance (TNF-α, tumor necrosis factor alpha reduced by 30–50%). The most positive impact of ALA and SDA was the beneficial reduction of total lipids (from 395 ± 3 to 352–361 mg/dL), VLDL-cholesterol (from 21.8 ± 0.2 to 14.1–17.8 mg/dL), and triacylglycerols (from 109 ± 1 to 71–89 mg/dL) in both LIN (diet enriched in linseed oil) and BUG (diet enriched in Buglossoides oil) groups. Overall, data indicate that ALA- and SDA-rich lipid sources may counteract the undesirable cardiovascular effects of a hypercaloric diet based on milk fat. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect