Serum testosterone and its relation to bone mineral density and body composition in normal males
| Autor: | La-or Chailurkit, Puavilai G, K. Teerarungsikul, Rajata Rajatanavin, Boonsong Ongphiphadhanakul, Rojana Sirisriro, Surat Komindr, Noppawan Piaseu |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male Aging medicine.medical_specialty medicine.drug_class Endocrinology Diabetes and Metabolism Osteoporosis Endocrinology Bone Density Internal medicine Blood plasma medicine Humans Testosterone Femur Aged Morning Femoral neck Aged 80 and over Bone mineral Trochanter business.industry Luteinizing Hormone Middle Aged medicine.disease Androgen Spine medicine.anatomical_structure Body Composition Follicle Stimulating Hormone business |
| Zdroj: | Clinical Endocrinology. 43:727-733 |
| ISSN: | 1365-2265 0300-0664 |
| Popis: | Summary OBJECTIVE Bone mineral density (BMD) declines with age in both men and women, predisposing the elderly to osteoporosis and fractures. Although there are extensive data about post-menopausal osteoporosis, there is relatively little information concerning the decrease in BMD with age in normal men, particularly the contribution of declining gonadal function with age to BMD. In the present study, we investigated the effect of age on the pituitary-gonadal axis in normal males and its relation to BMD and body composition. SUBJECTS Ninety healthy Thai males in the Bangkok Metropolitan area without a history of smoking or significant alcohol consumption were studied. MEASUREMENTS Serum testosterone (T), free testosterone (FT), LH and FSH were measured by radioimmunoassay in fasting blood samples obtained In the morning between 0600 and 1000h. BMD at anteroposterior L2-L4, lateral L2-L4, femoral neck, femoral trochanter and Ward's triangle were determined by dual-energy X-ray absorptiometry. RESULTS There were significant declines with age in BMD at lateral L2-L4 (r= 0.37, P < 0.001), femoral neck (r=−0.49, P |
| Databáze: | OpenAIRE |
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