Enhanced Susceptibility for Acquired Torsade de Pointes Arrhythmias in the Dog With Chronic, Complete AV Block Is Related to Cardiac Hypertrophy and Electrical Remodeling
| Autor: | Jack P.M. Cleutjens, J. J. Schreuder, H. D. M. Leunissen, S. H. M. de Groot, Hein J.J. Wellens, Mat J.A.P. Daemen, J. van der Zande, Maurits A. Allessie, Marc A. Vos, S. C. Verduyn, M. van Bilsen |
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| Rok vydání: | 1998 |
| Předmět: |
Male
Cardiac function curve Heart disease Heart block Heart Ventricles Action Potentials Gene Expression Hemodynamics Cardiomegaly Muscle hypertrophy Electrocardiography Norepinephrine Dogs Torsades de Pointes Ventricular hypertrophy Physiology (medical) Animals Medicine Sinus rhythm RNA Messenger biology business.industry Fissipedia Organ Size biology.organism_classification medicine.disease Adaptation Physiological Coronary Vessels Fibrosis Electrophysiology Disease Models Animal Heart Block Anesthesia Chronic Disease cardiovascular system Female Cardiology and Cardiovascular Medicine business Atrial Natriuretic Factor |
| Zdroj: | Circulation. 98:1125-1135 |
| ISSN: | 1524-4539 0009-7322 |
| DOI: | 10.1161/01.cir.98.11.1125 |
| Popis: | Background —Chronic, complete AV block (CAVB) in the dog leads to ventricular hypertrophy, which has been described as an independent risk factor for arrhythmias. In this model, we examined (1) whether the short- and long-term electrical adaptations predispose to acquired torsade de pointes arrhythmias (TdP) and (2) the nature of the structural and functional adaptations involved. Methods and Results —We determined (1) endocardial right (RV) and left (LV) ventricular APD, ΔAPD (LV APD−RV APD), presence of EADs at 0 weeks (acute: AAVB), and CAVB (6 weeks) and inducibility of TdP by pacing and d -sotalol (n=10); (2) steady-state and dynamic LV hemodynamics at 0 and 6 weeks (n=6); (3) plasma neurohumoral levels in time (n=7); (4) structural parameters of the LV and RV of CAVB dogs (n=6) compared with sinus rhythm (SR) dogs (n=6); and (5) expression of ventricular mRNA atrial natriuretic factor (ANF) in CAVB (n=4) and SR (n=4) dogs. Compared with AAVB, CAVB led to nonhomogeneous prolongation of LV and RV APD and different sensitivity for d -sotalol, leading to EADs (4 of 14 versus 9 of 18, P P P Conclusions —The electrical remodeling occurring after CAVB predisposes the heart to acquired TdP, whereas the structural changes (hypertrophy) are successfully aimed at maintaining cardiac function. |
| Databáze: | OpenAIRE |
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