One-hour post-load plasma glucose levels associated with decreased insulin sensitivity and secretion and early makers of cardiometabolic risk
| Autor: | M. L. Marcovecchio, Angelika Mohn, Valentina Chiavaroli, M. Bagordo, E. Marisi, T. de Giorgis, Francesco Chiarelli |
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| Přispěvatelé: | Marcovecchio, Loredana [0000-0002-4415-316X], Apollo - University of Cambridge Repository |
| Rok vydání: | 2019 |
| Předmět: |
Blood Glucose
Male endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Type 2 diabetes 030204 cardiovascular system & hematology Overweight Adolescents chemistry.chemical_compound 0302 clinical medicine Endocrinology Insulin Child Children Glucose tolerance test medicine.diagnostic_test Insulin secretion Insulin sensitivity Cardiovascular Diseases Child Preschool Female medicine.symptom medicine.medical_specialty Adolescent 030209 endocrinology & metabolism 03 medical and health sciences Insulin resistance Metabolic Diseases Internal medicine Cardio-metabolic risk Glucose Intolerance medicine Humans Obesity Retrospective Studies business.industry Cholesterol nutritional and metabolic diseases Anthropometry Glucose Tolerance Test medicine.disease chemistry Diabetes Mellitus Type 2 1-H plasma glucose Insulin Resistance business Biomarkers |
| DOI: | 10.17863/cam.25982 |
| Popis: | PURPOSE: Obese adults with normal glucose tolerance (NGT) but with 1-hour post-load plasma glucose (1hPG) ≥ 155 mg/dl are at higher risk of developing type 2 diabetes (T2D) and cardiometabolic complications. Little information is available for the pediatric population, where recently, a lower cutoff, 132.5 mg/dl, has been suggested as being more sensitive to identify subjects at risk of T2D. Our aim was to assess whether obese Caucasian youth with 1hPG ≥ 132.5 mg/dl have worse insulin sensitivity and secretion and a worse cardiometabolic profile compared to obese youth with 1hPG < 132.5 mg/dl. METHODS: Medical records of 244 (43% male; age: 11.1 ± 2.7years) overweight/obese children and adolescents, who had undergone an oral glucose tolerance test (OGTT), were retrieved. Anthropometric and biochemical data were collected from the hard copy archive. Indexes of insulin resistance (HOMA-IR), insulin sensitivity (WBISI), and insulin secretion (Insulinogenic Index, Disposition Index) were calculated. RESULTS: Of the 244 records analyzed, 215 fulfilled criteria for NGT and had complete biochemical data. Among NGT patients, 42 (19.5%) showed 1hPG ≥ 132.5 mg/dL (high-NGT), while the remaining had 1hPG < 132.5 mg/dL (low-NGT). The high-NGT group showed a higher male prevalence (59.5 vs 37%), lower Disposition Index (0.54 [0.39-0.71] vs 0.79 [0.47-1.43]), and WBISI (0.24 [0.18-0.35] vs 0.33 [0.23-0.50]) than the low-NGT group. High-NGT subjects also showed a trend towards lower HDL-cholesterol and higher triglycerides/HDL-cholesterol ratio (2.13 [1.49-3.41] vs 1.66 [1.24-2.49]). CONCLUSIONS: In overweight/obese NGT Caucasian youth a 1hPG ≥ 132.5 mg/dL was able to identify those with impaired insulin sensitivity and secretion and a trend towards a worse cardio-metabolic profile, a group likely at risk for future T2D. |
| Databáze: | OpenAIRE |
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