Dampened Mesolimbic Dopamine Function and Signaling by Saturated but not Monounsaturated Dietary Lipids
| Autor: | Christine Des Rosiers, Thierry Alquier, Cecile Hryhorczuk, Marc Florea, Isabelle Poirier, Demetra Rodaros, Caroline Daneault, Stephanie Fulton, Andreas Arvanitogiannis |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty medicine.medical_treatment Dopamine Dietary lipid Spatial Behavior Nucleus accumbens Motor Activity Palm Oil Diet High-Fat Nucleus Accumbens 03 medical and health sciences Random Allocation 0302 clinical medicine Dopamine receptor D1 Reward Internal medicine Conditioning Psychological medicine Animals Plant Oils Receptors AMPA Rats Wistar Amphetamine Olive Oil Pharmacology Chemistry Leptin Insulin Receptors Dopamine D1 Benzazepines Psychiatry and Mental health 030104 developmental biology Endocrinology Dopamine Agonists Central Nervous System Stimulants Original Article medicine.symptom Weight gain 030217 neurology & neurosurgery medicine.drug Signal Transduction |
| Zdroj: | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 41(3) |
| ISSN: | 1740-634X |
| Popis: | Overconsumption of dietary fat is increasingly linked with motivational and emotional impairments. Human and animal studies demonstrate associations between obesity and blunted reward function at the behavioral and neural level, but it is unclear to what degree such changes are a consequence of an obese state and whether they are contingent on dietary lipid class. We sought to determine the impact of prolonged ad libitum intake of diets rich in saturated or monounsaturated fat, separate from metabolic signals associated with increased adiposity, on dopamine (DA)-dependent behaviors and to identify pertinent signaling changes in the nucleus accumbens (NAc). Male rats fed a saturated (palm oil), but not an isocaloric monounsaturated (olive oil), high-fat diet exhibited decreased sensitivity to the rewarding (place preference) and locomotor-sensitizing effects of amphetamine as compared with low-fat diet controls. Blunted amphetamine action by saturated high-fat feeding was entirely independent of caloric intake, weight gain, and plasma levels of leptin, insulin, and glucose and was accompanied by biochemical and behavioral evidence of reduced D1R signaling in the NAc. Saturated high-fat feeding was also tied to protein markers of increased AMPA receptor-mediated plasticity and decreased DA transporter expression in the NAc but not to alterations in DA turnover and biosynthesis. Collectively, the results suggest that intake of saturated lipids can suppress DA signaling apart from increases in body weight and adiposity-related signals known to affect mesolimbic DA function, in part by diminishing D1 receptor signaling, and that equivalent intake of monounsaturated dietary fat protects against such changes. |
| Databáze: | OpenAIRE |
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