Features of the manifestation and course of Crohn’s disease in three brothers
| Autor: | A. V. Morkovina, E. Yu. Yuryeva, T. L. Lapina, P. V. Pavlov, A. S. Tertychnyy, A. A. Sheptulin |
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| Rok vydání: | 2021 |
| Předmět: |
Medicine (General)
medicine.medical_specialty Disease Vitiligo inflammatory bowel diseases Gastroenterology Resection manifestation of the disease 03 medical and health sciences Cecum R5-920 0302 clinical medicine Internal medicine hereditary predisposition medicine Terminal ileum Ascending colon autoimmune diseases Significant risk business.industry medicine.disease crohn’s disease medicine.anatomical_structure 030220 oncology & carcinogenesis Rheumatoid arthritis 030211 gastroenterology & hepatology business |
| Zdroj: | Сеченовский вестник, Vol 11, Iss 3, Pp 70-77 (2021) |
| ISSN: | 2658-3348 2218-7332 |
| Popis: | Hereditary predisposition is the most significant risk factor for Crohn’s disease (CD) in siblings. Case reports. CD was diagnosed in 3 brothers in a family with 6 children of the same generation: the disease manifested itself in one — at the age of 15 years and in two brothers — at the age of 17 years. In the older brother, CD manifested with acute intestinal obstruction, ileum perforation, diffuse peritonitis; in the middle — with symptoms similar to appendicular infiltrate. Both brothers underwent resection of the terminal ileum, cecum, and part of the ascending colon with the imposition of ileoascendoanastomosis. The younger brother was diagnosed with a non-stricturing, non-penetrating form of CD with a gradual onset and no complications. Among the siblings without CD, two have rheumatoid arthritis and vitiligo. Discussion. Similar signs of the familial form of CD were young age of manifestation and ileocolonic disease location; distinctive signs — the presence of complications and surgical interventions in only two brothers. A special feature of the case reports is the CD development only in boys and the combination of three different autoimmune diseases in one generation of the family. |
| Databáze: | OpenAIRE |
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