Mouse Ptchd3 is a non-essential gene
| Autor: | Heath Blankenship, Shaimar R. González Morales, Guo-Zhang Zhu, Chengjing Liu |
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| Rok vydání: | 2019 |
| Předmět: |
Patched
lcsh:QH426-470 Knockout Mutant Embryonic Development Hedgehog signaling Receptors Cell Surface Biology Ptchd3 Article Dhh desert hedgehog Mice Genetics Animals Spermatogenesis Hedgehog Gene Mice Knockout Genes Essential Gene Expression Regulation Developmental General Medicine Sperm Hedgehog signaling pathway Cell biology lcsh:Genetics Germ Cells Essential gene Organ Specificity Knockout mouse Hh hedgehog Male germ cells Ptchd3 patched domain containing 3 |
| Zdroj: | Gene: X Gene: X, Vol 5, Iss, Pp 100032-(2020) |
| ISSN: | 1879-0038 |
| Popis: | Mouse Ptchd3 (patched domain containing 3) was previously identified as a male germ-cell specific gene. The protein product of this gene has been found on the surface of mouse, rat and human sperm. Since Ptchd3 contains a conserved patched domain, we hypothesize that it functions as a membrane receptor for the hedgehog ligand. Herein, we used a Ptchd3 knockout mouse model to study its function in mouse development and spermatogenesis. We found that Ptchd3 knockout mice were born and lived normally. The fertility and sperm production of knockout males were not changed. Moreover, our data indicated that the expression levels of several hedgehog signaling genes were not affected in mutant testis. Taken together, these findings demonstrate that Ptchd3 is a non-essential gene in mouse development and spermatogenesis. |
| Databáze: | OpenAIRE |
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