Exogenous luteinizing hormone in controlled ovarian hyperstimulation for assisted reproduction techniques
| Autor: | Valeria Farfalli, Luca Gianaroli, Arianna D'Angelo, N. Montanaro, Anna Pia Ferraretti, Maria Cristina Magli |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Pregnancy Rate Reproductive Techniques Assisted medicine.drug_class medicine.medical_treatment Drug Resistance Controlled ovarian hyperstimulation Reproductive technology Biology Andrology Follicle-stimulating hormone Ovulation Induction Pregnancy Internal medicine medicine Humans Embryo Implantation Prospective Studies Dose-Response Relationship Drug Incidence Pregnancy Outcome Obstetrics and Gynecology Luteinizing Hormone Embryo Transfer Recombinant Proteins Embryo transfer Pregnancy rate Endocrinology Reproductive Medicine Case-Control Studies Female Ovulation induction Follicle Stimulating Hormone Gonadotropin Luteinizing hormone |
| Zdroj: | Fertility and Sterility. 82:1521-1526 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/j.fertnstert.2004.06.041 |
| Popis: | Objective To investigate the role of exogenous LH in controlled ovarian hyperstimulation for assisted reproductive technologies. Design Prospective randomized study. Setting SISMER fertility unit. Patient(s) Women showing a hyporesponsiveness to FSH under GnRH agoinst down-regulation were randomized into three groups: group A (n = 54) received an increased dosage of FSH; group B (n = 54) was administered recombinant LH in addition to the increased dose of FSH; group C (n = 22) was given additional FSH and LH using hMG as a combined drug. Fifty-four age-matched women with no need to increase the FSH dose were included as a control group (D). Intervention(s) None. Main outcome measure(s) Implantation and live birth rate per started cycles. Result(s) In group B, the pregnancy and implantation rates were statistically higher when compared with groups A and C and did not differ from the control group for normal response. The live birth rate was similar in groups B and D but was half as high in groups A and C. Conclusion(s) Hyporesponsiveness to FSH could be related to iatrogenic LH deficiency that, in turn, could affect oocyte competence. Addition of a small amount of recombinant LH is able to rescue oocyte competence to produce viable embryos. |
| Databáze: | OpenAIRE |
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