Antral gastrin and somatostatin concentrations in peptic ulcer patients
| Autor: | E. Sanuki, S. Tsumaru, Y. Matsumoto, K. Hirata, Koji Sumii, Masaaki Sumioka, Akima Miyoshi, T. Fukushima, Yukitaka Miyachi |
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| Rok vydání: | 1981 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Physiology Atrophic gastritis digestive system Biochemistry Gastroenterology Gastric Acid Pathogenesis Cellular and Molecular Neuroscience Endocrinology Internal medicine Gastrins Pyloric Antrum medicine Humans Stomach Ulcer Antrum Gastrin business.industry digestive oral and skin physiology Middle Aged medicine.disease digestive system diseases Somatostatin Duodenal Ulcer Peptic ulcer Gastric acid Gastritis medicine.symptom business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Peptides. 2:281-283 |
| ISSN: | 0196-9781 |
| DOI: | 10.1016/0196-9781(81)90046-2 |
| Popis: | As an attempt to approach the pathogenesis of peptic ulcer disease, antral gastrin and somatostatin concentrations were studied in normal subjects, patients with duodenal ulcer and gastric ulcer. In the patients with peptic ulcer, antral somatostatin concentrations were significantly lower than those in normal subjects. In non-ulcer subjects, including normal subjects and patients with atrophic gastritis, antral somatostatin concentrations were correlated inversely with the degree of antral gastritis, while in the patients with peptic ulcer, especially in duodenal ulcer, they were low, irrespective of histological picture of antral mucosa. In the patients with duodenal ulcer, low antral somatostatin concentrations with high antral gastrin/somatostatin ratio may cause increased serum gastrin levels and increased gastric acid secretion. From the above findings, it has been concluded that low antral somatostatin levels may be related to the pathogenesis of duodenal ulcer disease. |
| Databáze: | OpenAIRE |
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