HLA antigens in Italian multiple sclerosis patients
| Autor: | G. Pellegris, Angelo Nespolo, M. T. Illeni, Clara Milanese, L. La Mantia, Andrea Salmaggi, Marica Eoli |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Neurology Multiple Sclerosis Disease Human leukocyte antigen HLA-C Antigens Intrathecal Cerebrospinal fluid Immune system Antigen HLA Antigens Reference Values HLA-DQ Antigens Medicine Humans HLA-A Antigens business.industry General Neuroscience Multiple sclerosis HLA-DR Antigens medicine.disease Italy HLA-B Antigens Immunoglobulin G Immunology Neurology (clinical) business |
| Zdroj: | Italian journal of neurological sciences. 12(1) |
| ISSN: | 0392-0461 |
| Popis: | We analyzed HLA-A, -C, -B, -DR and -DQ specificities in 104 Italian multiple sclerosis patients and in 905 healthy controls. The frequencies of HLA-A23, A26, Cw4, DR3 and, especially DR5 antigens were significantly higher in multiple sclerosis patients than in controls. Patients with progressive course were characterized by high frequencies of B7, B8 and DR3 antigens: Cw1 and DRw11 shows a negative correlation with the extent of intrathecal IgG production. These data confirm that the HLA system may influence the clinical expression and the immune responses to the disease. |
| Databáze: | OpenAIRE |
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