The Role of Zinc in Axon Formation via the mTORC1 Pathway

Autor: Seunghyuk Choi, Donghyeon Kang, Jieun Kang, Dae Ki Hong, Beom Seok Kang, A Ra Kho, Bo Young Choi, Sung-Oh Huh, Sang Won Suh
Rok vydání: 2022
Předmět:
Zdroj: Molecular Neurobiology. 59:3206-3217
ISSN: 1559-1182
0893-7648
DOI: 10.1007/s12035-022-02785-8
Popis: Zinc is an essential micronutrient required for proper function during neuronal development because it can modulate neuronal function and structure. A fully functional description of zinc in axonal processing in the central nervous system remains elusive. Here, we define the role of intracellular zinc in axon formation and elongation, involving the mammalian target of rapamycin complex 1 (mTORC1). To investigate the involvement of zinc in axon growth, we performed an ex vivo culture of mouse hippocampal neurons and administrated ZnCl
Databáze: OpenAIRE
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